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Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells

Overview of attention for article published in Molecular Cancer, February 2018
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Title
Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
Published in
Molecular Cancer, February 2018
DOI 10.1186/s12943-018-0775-3
Pubmed ID
Authors

Shaocong Wu, Liwu Fu

Abstract

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no commercial available MDR modulator approved by FDA was used in clinic. Tyrosine kinase inhibitors (TKIs) have been administrated to fight against cancer for decades. Almost TKI was used alone in clinic. However, drug combinations acting synergistically to kill cancer cells have become increasingly important in cancer chemotherapy as an approach for the recurrent resistant disease. Here, we summarize the effect of TKIs on enhancing the efficacy of conventional chemotherapeutic drug in ABC transporter-mediated MDR cancer cells, which encourage to further discuss and study in clinic.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 21%
Researcher 5 18%
Student > Ph. D. Student 4 14%
Student > Bachelor 2 7%
Professor > Associate Professor 2 7%
Other 3 11%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 5 18%
Biochemistry, Genetics and Molecular Biology 4 14%
Agricultural and Biological Sciences 3 11%
Chemistry 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 2 7%
Unknown 9 32%