Title |
Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults
|
---|---|
Published in |
Journal of Hypertension, July 2018
|
DOI | 10.1097/hjh.0000000000001728 |
Pubmed ID | |
Authors |
Mark G. Filipovic, Stefanie Aeschbacher, Martin F. Reiner, Simona Stivala, Sara Gobbato, Nicole Bonetti, Martin Risch, Lorenz Risch, Giovanni G. Camici, Thomas F. Luescher, Clemens von Schacky, David Conen, Juerg H. Beer |
Abstract |
Omega-3 fatty acids (n - 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n - 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals' omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults. The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25-41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders. Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was -2.67 mmHg (-4.83; -0.51; P = 0.02) and -2.30 mmHg (-3.92; -0.68; P = 0.005) for 24-h SBP and DBP, respectively. A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n - 3 FA may be a strategy for primary prevention of hypertension. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 19% |
Researcher | 8 | 15% |
Student > Bachelor | 7 | 13% |
Student > Doctoral Student | 3 | 6% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 15% |
Unknown | 15 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Nursing and Health Professions | 6 | 11% |
Agricultural and Biological Sciences | 4 | 7% |
Chemistry | 3 | 6% |
Other | 8 | 15% |
Unknown | 18 | 33% |