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Structure, chromosomal localization, and expression of 12 genes of the MAGE family

Overview of attention for article published in Immunogenetics, September 1994
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 1,064)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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60 patents
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8 Wikipedia pages

Citations

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447 Dimensions

Readers on

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23 Mendeley
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Title
Structure, chromosomal localization, and expression of 12 genes of the MAGE family
Published in
Immunogenetics, September 1994
DOI 10.1007/bf01246677
Pubmed ID
Authors

Etienne De Plaen, Catia Traversari, José J. Gaforio, Jean-Pierre Szikora, Charles De Smet, Francis Brasseur, Pierre van der Bruggen, Bernard Lethé, Christophe Lurquin, Patrick Chomez, Olivier De Backer, Thierry Boon, Karen Arden, Webster Cavenee, Robert Brasseur

Abstract

We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries with a MAGE-1 sequence, we identified 11 closely related genes. The analysis of hamster-human somatic cell hybrids indicated that the 12 MAGE genes are located in the q terminal region of chromosome X. Like MAGE-1, the 11 additional MAGE genes have their entire coding sequence located in the last exon, which shows 64%-85% identity with that of MAGE-1. The coding sequences of the MAGE genes predict the same main structural features for all MAGE proteins. In contrast, the promoters and first exons of the 12 MAGE genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The expression of each MAGE gene was evaluated by reverse transcription and polymerase chain reaction amplification. Six genes of the MAGE family including MAGE-1 were found to be expressed at a high level in a number of tumors of various histological types. None was expressed in a large panel of healthy tissues, with the exception of testis and placenta.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 26%
Student > Master 6 26%
Other 4 17%
Researcher 3 13%
Student > Doctoral Student 1 4%
Other 2 9%
Unknown 1 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 39%
Medicine and Dentistry 6 26%
Agricultural and Biological Sciences 4 17%
Immunology and Microbiology 1 4%
Business, Management and Accounting 1 4%
Other 0 0%
Unknown 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2018.
All research outputs
#1,185,743
of 13,055,200 outputs
Outputs from Immunogenetics
#11
of 1,064 outputs
Outputs of similar age
#29,273
of 277,656 outputs
Outputs of similar age from Immunogenetics
#1
of 13 outputs
Altmetric has tracked 13,055,200 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,064 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,656 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.