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Erythropoiesis: insights into pathophysiology and treatments in 2017

Overview of attention for article published in Molecular Medicine, March 2018
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1 tweeter

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211 Mendeley
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Title
Erythropoiesis: insights into pathophysiology and treatments in 2017
Published in
Molecular Medicine, March 2018
DOI 10.1186/s10020-018-0011-z
Pubmed ID
Authors

Andrea Zivot, Jeffrey M. Lipton, Anupama Narla, Lionel Blanc

Abstract

Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte.Altered red cell production can result from the direct impairment of medullary erythropoiesis, as seen in the thalassemia syndromes, inherited bone marrow failure as well as in the anemia of chronic disease. Alternatively, in disorders such as sickle cell disease (SCD) as well as enzymopathies and membrane defects, medullary erythropoiesis is not, or only minimally, directly impaired. Despite these differences in pathophysiology, therapies have traditionally been non-specific, limited to symptomatic control of anemia via packed red blood cell (pRBC) transfusion, resulting in iron overload and the eventual need for iron chelation or splenectomy to reduce defective red cell destruction. Likewise, in polycythemia vera overproduction of red cells has historically been dealt with by non-specific myelosuppression or phlebotomy. With a deeper understanding of the molecular mechanisms underlying disease pathophysiology, new therapeutic targets have been identified including induction of fetal hemoglobin, interference with aberrant signaling pathways and gene therapy for definitive cure. This review, utilizing some representative disorders of erythropoiesis, will highlight novel therapeutic modalities currently in development for treatment of red cell disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 211 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 34 16%
Student > Master 27 13%
Student > Ph. D. Student 23 11%
Researcher 16 8%
Student > Postgraduate 13 6%
Other 28 13%
Unknown 70 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 53 25%
Medicine and Dentistry 38 18%
Agricultural and Biological Sciences 13 6%
Nursing and Health Professions 5 2%
Unspecified 5 2%
Other 22 10%
Unknown 75 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2019.
All research outputs
#13,820,330
of 15,665,714 outputs
Outputs from Molecular Medicine
#725
of 818 outputs
Outputs of similar age
#242,901
of 280,314 outputs
Outputs of similar age from Molecular Medicine
#1
of 1 outputs
Altmetric has tracked 15,665,714 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 818 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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