| Title |
Solid Organ Transplantation in Patients With Preexisting Malignancies in Remission
|
|---|---|
| Published in |
Transplantation, July 2018
|
| DOI | 10.1097/tp.0000000000002178 |
| Pubmed ID | |
| Authors |
Sergio A. Acuna, Rinku Sutradhar, S. Joseph Kim, Nancy N. Baxter |
| Abstract |
Solid organ transplant recipients (SOTR) with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. All SOTR in Ontario between 1991 and 2010 were identified and matched 1:2 to recipients without PTM using a propensity score. OS was compared using the Kaplan-Meier estimator and Cox proportional hazard models. For cancer-specific mortality and cancer recurrence, cause-specific hazard models were used and the cumulative incidence was plotted. Recipients with PTM had a worse OS compared to recipients without PTM (median OS: 10.3 versus 13.4 years). Recipients with PTM were not only at increased risk of cancer-specific mortality (CSHR:1.85 [95%CI: 1.20, 2.86]) but also at increased risk of noncancer death (CSHR:1.29 [95%CI: 1.08, 1.54]). Compared to recipients without PTM, recipients with high-risk PTM had higher all-cause mortality (HR:1.81 [95%CI: 1.47, 2.23]). Recipients with low-risk PTM were not at increased risk (HR:1.06 [95%CI: 0.86, 1.31]). Recipients with PTM are at increased risk of all-cause mortality compared to recipients without PTM. This increased risk was noted for both cancer-specific and noncancer mortality. However, only those with high-risk PTM had worse outcomes. |
Twitter Demographics
The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 5 | 26% |
| Spain | 4 | 21% |
| Netherlands | 1 | 5% |
| Mexico | 1 | 5% |
| Italy | 1 | 5% |
| Ecuador | 1 | 5% |
| Unknown | 6 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 74% |
| Scientists | 2 | 11% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 6 | 29% |
| Researcher | 4 | 19% |
| Professor | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Student > Master | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 62% |
| Arts and Humanities | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Unspecified | 1 | 5% |
| Unknown | 5 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2019.
All research outputs
#3,445,042
of 24,040,389 outputs
Outputs from Transplantation
#612
of 7,390 outputs
Outputs of similar age
#67,948
of 331,754 outputs
Outputs of similar age from Transplantation
#13
of 101 outputs
Altmetric has tracked 24,040,389 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,390 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.