Title |
Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats 1
|
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Published in |
Acta Cirúrgica Brasileira, February 2018
|
DOI | 10.1590/s0102-865020180020000010 |
Pubmed ID | |
Authors |
Paulo Henrique Muleta Andrade, Luciane Canderolo Portugal, Eric Schmidt Rondon, Monica Cristina Toffoli Kadri, Maria de Fátima Cepa Matos |
Abstract |
To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential. Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups: Control group (GC.diab), no therapeutic intervention on the wound; Vehicle's Control group, topical via, in diabetic rats (GCvt.diab): Powder Shell Group (PC) applied topically (GPCvt.diab): Experimental group was administered topically shortly after wound dressing and once a day during the experimental period (3, 7, 14 and 21 days) the composition containing the powdered shell of the snail. The following variables related to the healing potential were analyzed: macroscopic one, where the capacity of reduction of the wound area was evaluated; histological analysis in HE, angiogenic activity, morphometric analysis (re-epithelization), leukocyte inflammatory infiltrate; leukocyte count and also differentiation in peripheral blood. The topical application in wounds of diabetic rats presented healing activity, accelerating wound closure, stimulating angiogenesis and being pro-inflammatory in the early and anti-inflammatory stages in the final times of the healing process. The topical administration of the powdered shell on wounds of diabetic patients becomes a therapeutic option of low cost, with ease in the administration and access as well. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 19% |
Student > Doctoral Student | 4 | 11% |
Student > Master | 3 | 8% |
Other | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 3 | 8% |
Unknown | 15 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 11% |
Nursing and Health Professions | 4 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Medicine and Dentistry | 3 | 8% |
Engineering | 2 | 6% |
Other | 5 | 14% |
Unknown | 15 | 42% |