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Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight

Overview of attention for article published in Journal of Molecular Medicine, December 2006
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#29 of 1,108)
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
patent
1 patent
wikipedia
2 Wikipedia pages

Citations

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115 Dimensions

Readers on

mendeley
76 Mendeley
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Title
Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight
Published in
Journal of Molecular Medicine, December 2006
DOI 10.1007/s00109-006-0131-8
Pubmed ID
Authors

S. Apostolidou, S. Abu-Amero, K. O’Donoghue, J. Frost, O. Olafsdottir, K. M. Chavele, J. C. Whittaker, P. Loughna, P. Stanier, G. E. Moore

Abstract

The identification of genes that regulate fetal growth will help establish the reasons for intrauterine growth restriction. Most autosomal genes are expressed biallelically, but some are imprinted, expressed only from one parental allele. Imprinted genes are associated with fetal growth and development. The growth of the fetus in utero relies on effective nutrient transfer from the mother to the fetus via the placenta. Some current research on the genetic control of fetal growth has focused on genes that display imprinted expression in utero. The expression levels of four imprinted genes, the paternally expressed insulin growth factor 2 (IGF2), the mesoderm-specific transcript isoform 1 (MEST); the maternally expressed pleckstrin homology-like domain, family A, member 2 (PHLDA2); and the polymorphically imprinted insulin-like growth factor 2 (IGF2R) gene are all known to have roles in fetal growth and were studied in the placentae of 200 white European, normal term babies. The quantitative expression analysis with real-time PCR showed the maternally expressing PHLDA2 but not the paternally expressing IGF2 and MEST, nor the polymorphic maternally expressing IGF2R placental levels to have a statistically significant effect on birth weight. PHLDA2 expression levels are negatively correlated with size at birth. These data implicate PHLDA2 as an imprinted gene important in fetal growth and also as a potential marker of fetal growth.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
Japan 1 1%
Australia 1 1%
United Kingdom 1 1%
Unknown 71 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Researcher 16 21%
Student > Bachelor 11 14%
Student > Master 10 13%
Student > Doctoral Student 6 8%
Other 12 16%
Unknown 4 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 42%
Medicine and Dentistry 17 22%
Biochemistry, Genetics and Molecular Biology 13 17%
Nursing and Health Professions 3 4%
Sports and Recreations 1 1%
Other 1 1%
Unknown 9 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#1,135,674
of 13,309,886 outputs
Outputs from Journal of Molecular Medicine
#29
of 1,108 outputs
Outputs of similar age
#27,286
of 278,935 outputs
Outputs of similar age from Journal of Molecular Medicine
#3
of 23 outputs
Altmetric has tracked 13,309,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,108 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.