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Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis

Overview of attention for article published in Febs Letters, July 2004
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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5 Wikipedia pages

Citations

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21 Dimensions

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22 Mendeley
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Title
Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis
Published in
Febs Letters, July 2004
DOI 10.1016/j.febslet.2004.06.068
Pubmed ID
Authors

Andrew J Lindsay, Mary W McCaffrey

Abstract

Rab coupling protein (RCP) is a member of the Rab11-family of interacting proteins (Rab11-FIPs). Family members are characterised by their ability to interact with Rab11. This property is mediated by a conserved Rab binding domain (RBD) located at their carboxy-termini. Several Rab11-FIPs can also interact with other small GTPases. RCP interacts with Rab4 in addition to Rab11. To dissect out the individual properties of the Rab4 and Rab11 interactions with RCP, conserved amino acids within the RBD of RCP were mutated by site-directed mutagenesis. The effect of these mutations on Rab4 and Rab11 binding, and the intracellular localisation of RCP, was examined. Our results indicate that Rab11, rather than Rab4, mediates the intracellular localisation of RCP, and that the class I Rab11-FIPs compete for binding to Rab11.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Korea, Republic of 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 32%
Student > Ph. D. Student 7 32%
Student > Bachelor 3 14%
Professor > Associate Professor 3 14%
Other 1 5%
Other 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 55%
Biochemistry, Genetics and Molecular Biology 7 32%
Chemistry 2 9%
Environmental Science 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#817,720
of 3,627,218 outputs
Outputs from Febs Letters
#145
of 3,393 outputs
Outputs of similar age
#24,602
of 94,905 outputs
Outputs of similar age from Febs Letters
#2
of 27 outputs
Altmetric has tracked 3,627,218 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 3,393 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,905 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.