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Identification and antifungal susceptibility of Candida species isolated from the urine of patients in a university hospital in Brazil

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, December 2017
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Title
Identification and antifungal susceptibility of Candida species isolated from the urine of patients in a university hospital in Brazil
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, December 2017
DOI 10.1590/s1678-9946201759075
Pubmed ID
Authors

Gláucia Moreira Espíndola Lima, Maína de Oliveira Nunes, Marilene Rodrigues Chang, Rosianne Assis de Sousa Tsujisaki, Joslaine de Oliveira Nunes, Cleison Ledesma Taira, Danilo Yamamoto Thomaz, Gilda Maria Bárbaro Del Negro, Rinaldo Pôncio Mendes, Anamaria Mello Miranda Paniago

Abstract

The aim of this study was to identify Candida spp. isolated from candiduria episodes at a tertiary hospital in the Midwest region of Brazil, and to determine their susceptibility profiles to antifungal compounds. From May 2011 to April 2012, Candida spp. isolated from 106 adult patients with candiduria admitted to the University Hospital of the Federal University of Mato Grosso do Sul were evaluated. Both, species identification and susceptibility testing with fluconazole-FLC, voriconazole-VRC, and amphotericin B-AmB were carried out using the Vitek 2. To discriminate species of the C. parapsilosis complex, a RAPD-PCR technique using the RPO2 primer was performed. From the total of 106 isolates, 42 (39.6%) C. albicans and 64 (60.4%) Candida non-albicans (CNA) - 33 C. tropicalis, 18 C. glabrata, 5 C. krusei, 4 C. parapsilosis sensu stricto, 2 C. kefyr, 1 C. lusitaniae, and 1 C. guilliermondii were identified. All isolates were susceptible to AmB and VRC, whereas all C. glabrata isolates presented either resistance (5.6%) or dose-dependent susceptibility (94.4%) to FLC. The study of Candida spp. and their resistance profiles may help in tailoring more efficient therapeutic strategies for candiduria.

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Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 6 15%
Student > Ph. D. Student 5 13%
Student > Bachelor 5 13%
Other 2 5%
Professor > Associate Professor 2 5%
Other 6 15%
Unknown 13 33%
Readers by discipline Count As %
Medicine and Dentistry 5 13%
Immunology and Microbiology 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Biochemistry, Genetics and Molecular Biology 3 8%
Nursing and Health Professions 3 8%
Other 3 8%
Unknown 16 41%