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Mendeley readers
Attention Score in Context
| Title |
Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
|
|---|---|
| Published in |
Nature Genetics, January 2001
|
| DOI | 10.1038/83685 |
| Pubmed ID | |
| Authors |
Miklós Péterfy, Jack Phan, Ping Xu, Karen Reue |
| Abstract |
Mice carrying mutations in the fatty liver dystrophy (fld) gene have features of human lipodystrophy, a genetically heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance. Through positional cloning, we have isolated the gene responsible and characterized two independent mutant alleles, fld and fld(2J). The gene (Lpin1) encodes a novel nuclear protein which we have named lipin. Consistent with the observed reduction of adipose tissue mass in fld and fld(2J)mice, wild-type Lpin1 mRNA is expressed at high levels in adipose tissue and is induced during differentiation of 3T3-L1 pre-adipocytes. Our results indicate that lipin is required for normal adipose tissue development, and provide a candidate gene for human lipodystrophy. Lipin defines a novel family of nuclear proteins containing at least three members in mammalian species, and homologs in distantly related organisms from human to yeast. |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Spain | 1 | <1% |
| Ireland | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 157 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 28% |
| Researcher | 26 | 16% |
| Student > Master | 19 | 12% |
| Student > Doctoral Student | 13 | 8% |
| Professor | 11 | 7% |
| Other | 32 | 20% |
| Unknown | 17 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 37% |
| Agricultural and Biological Sciences | 51 | 31% |
| Medicine and Dentistry | 12 | 7% |
| Neuroscience | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 23 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#4,696,560
of 22,788,370 outputs
Outputs from Nature Genetics
#4,225
of 7,187 outputs
Outputs of similar age
#11,506
of 114,248 outputs
Outputs of similar age from Nature Genetics
#24
of 54 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.