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Mendeley readers
Attention Score in Context
| Title |
hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
|
|---|---|
| Published in |
Molecular Cancer, September 2005
|
| DOI | 10.1186/1476-4598-4-32 |
| Pubmed ID | |
| Authors |
Renty B Franklin, Pei Feng, B Milon, Mohamed M Desouki, Keshav K Singh, André Kajdacsy-Balla, Omar Bagasra, Leslie C Costello |
| Abstract |
The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified. The peripheral zone is the major region of the human prostate gland where malignancy develops. The normal peripheral zone glandular epithelium has the unique function of accumulating high levels of zinc. In contrast, the ability to accumulate zinc is lost in the malignant cells. The lost ability of the neoplastic epithelial cells to accumulate zinc is a consistent factor in their development of malignancy. Recent studies identified ZIP1 (SLC39A1) as an important zinc transporter involved in zinc accumulation in prostate cells. Therefore, we investigated the possibility that down-regulation of hZIP1 gene expression might be involved in the inability of malignant prostate cells to accumulate zinc. To address this issue, the expression of hZIP1 and the depletion of zinc in malignant versus non-malignant prostate glands of prostate cancer tissue sections were analyzed. hZIP1 expression was also determined in malignant prostate cell lines. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Mexico | 1 | <1% |
| Thailand | 1 | <1% |
| Unknown | 98 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 25% |
| Student > Bachelor | 13 | 13% |
| Researcher | 9 | 9% |
| Student > Master | 9 | 9% |
| Professor | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 28 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 20% |
| Biochemistry, Genetics and Molecular Biology | 16 | 16% |
| Medicine and Dentistry | 14 | 14% |
| Chemistry | 10 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 6 | 6% |
| Unknown | 30 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2007.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Molecular Cancer
#547
of 1,719 outputs
Outputs of similar age
#20,431
of 58,704 outputs
Outputs of similar age from Molecular Cancer
#2
of 3 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,704 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.