Title |
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots
|
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Published in |
Molecular Cancer, May 2006
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DOI | 10.1186/1476-4598-5-17 |
Pubmed ID | |
Authors |
Leslie C Costello, Renty B Franklin |
Abstract |
The genetic and molecular mechanisms responsible for and associated specifically with the development and progression of malignant prostate cells are largely unidentified. In addition, despite its implication in virtually all malignant cells, the role of altered cellular metabolism as an essential factor in prostate malignancy has been largely ignored. Moreover, the intermediary metabolism of normal prostate as well as malignant prostate cells is among the least studied and most poorly understood of all mammalian cells. Some important factors, especially the role of zinc, have been identified and implicated in the development and progression of prostate malignancy. In this review, we provide a current and updated integrated assessment of the relationships of intermediary metabolism in normal prostate and in prostate cancer. The experimental and clinical evidence that leads to the formulation of concepts of normal and malignant prostate metabolism is presented. The evidence for a concept of zinc as a tumor suppressor agent and Zip1 zinc transporter as a tumor-suppressor gene is described. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
India | 2 | <1% |
United Kingdom | 2 | <1% |
Canada | 1 | <1% |
Netherlands | 1 | <1% |
Thailand | 1 | <1% |
Singapore | 1 | <1% |
Spain | 1 | <1% |
Lebanon | 1 | <1% |
Other | 0 | 0% |
Unknown | 224 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 51 | 22% |
Researcher | 34 | 14% |
Student > Bachelor | 33 | 14% |
Student > Master | 32 | 14% |
Professor > Associate Professor | 13 | 6% |
Other | 43 | 18% |
Unknown | 30 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 21% |
Medicine and Dentistry | 42 | 18% |
Biochemistry, Genetics and Molecular Biology | 38 | 16% |
Chemistry | 24 | 10% |
Engineering | 9 | 4% |
Other | 29 | 12% |
Unknown | 44 | 19% |