Title |
Hyperchloraemia in sepsis
|
---|---|
Published in |
Annals of Intensive Care, March 2018
|
DOI | 10.1186/s13613-018-0388-4 |
Pubmed ID | |
Authors |
Christos Filis, Ioannis Vasileiadis, Antonia Koutsoukou |
Abstract |
Chloride represents-quantitatively-the most prevalent, negatively charged, strong plasma electrolyte. Control of chloride concentration is a probable major mechanism for regulating the body's acid-base balance and for maintaining homeostasis of the entire internal environment. The difference between the concentrations of chloride and sodium constitutes the major contributor to the strong ion difference (SID); SID is the key pH regulator in the body, according to the physicochemical approach. Hyperchloraemia resulting from either underlying diseases or medical interventions is common in intensive care units. Recent studies have demonstrated the importance of hyperchloraemia in metabolic acidosis and in other pathophysiological disorders present in sepsis. The aim of this narrative review is to present the current knowledge about the effects of hyperchloraemia, in relation to the underlying pathophysiology, in septic patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 107 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 18 | 17% |
Student > Master | 13 | 12% |
Student > Postgraduate | 9 | 8% |
Student > Bachelor | 9 | 8% |
Student > Doctoral Student | 8 | 7% |
Other | 24 | 22% |
Unknown | 26 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 50% |
Nursing and Health Professions | 7 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 8 | 7% |
Unknown | 29 | 27% |