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Chromothripsis

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Cover of 'Chromothripsis'

Table of Contents

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    Book Overview
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    Chapter 1 The Genomic Characteristics and Origin of Chromothripsis
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    Chapter 2 Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
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    Chapter 3 Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
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    Chapter 4 Chromothripsis and the Macroevolution Theory
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    Chapter 5 Analysis of Chromothripsis by Combined FISH and Microarray Analysis
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    Chapter 6 Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
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    Chapter 7 Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
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    Chapter 8 Detection of Chromothripsis in Plants
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    Chapter 9 RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
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    Chapter 10 Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
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    Chapter 11 A Role for Retrotransposons in Chromothripsis
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    Chapter 12 Generation of Micronuclei and Detection of Chromosome Pulverization
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    Chapter 13 Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
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    Chapter 14 Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 15 Genes, Proteins, and Biological Pathways Preventing Chromothripsis
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    Chapter 16 Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 17 Chromothripsis Detection and Characterization Using the CTLPScanner Web Server
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    Chapter 18 ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
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    Chapter 19 Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos
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    Chapter 20 Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
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    Chapter 21 Experimental Induction of Genome Chaos
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    Chapter 22 Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis
Attention for Chapter 7: Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
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Chapter title
Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
Chapter number 7
Book title
Chromothripsis
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7780-2_7
Pubmed ID
Book ISBNs
978-1-4939-7779-6, 978-1-4939-7780-2
Authors

Veronica Ortega, Christina Mendiola, Gopalrao V. N. Velagaleti

Abstract

One of the well-known hallmarks of cancer is genomic instability. Although gradualism is a well-established process of cancer evolution, recent studies have shown that chromothripsis or chromoanasynthesis can result in complex genomic rearrangements by a single catastrophic event rather than several incremental steps. These two novel phenomena suggest an evolutionary modality for cancer cells to circumvent individual mutational events with one simultaneous shattering of chromosomes or chromosome regions resulting in the random reassembling of shattered genetic material to form complex derivative chromosomes. Although sequencing methods are ideal for the detection of chromothripsis, single-nucleotide polymorphism (SNP)-based microarray methods are also useful in detecting chromothripsis in biopsy samples. Issues related to sample collection, storage, and transport, especially with tumor biopsies, may limit the options for sequencing studies, and in such cases, SNP-based microarray may be a viable alternative for detecting chromothripsis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 50%
Student > Bachelor 1 25%
Student > Master 1 25%
Readers by discipline Count As %
Medicine and Dentistry 2 50%
Biochemistry, Genetics and Molecular Biology 1 25%
Unknown 1 25%