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Chromothripsis

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Cover of 'Chromothripsis'

Table of Contents

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    Book Overview
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    Chapter 1 The Genomic Characteristics and Origin of Chromothripsis
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    Chapter 2 Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
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    Chapter 3 Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
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    Chapter 4 Chromothripsis and the Macroevolution Theory
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    Chapter 5 Analysis of Chromothripsis by Combined FISH and Microarray Analysis
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    Chapter 6 Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
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    Chapter 7 Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
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    Chapter 8 Detection of Chromothripsis in Plants
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    Chapter 9 RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
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    Chapter 10 Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
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    Chapter 11 A Role for Retrotransposons in Chromothripsis
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    Chapter 12 Generation of Micronuclei and Detection of Chromosome Pulverization
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    Chapter 13 Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
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    Chapter 14 Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 15 Genes, Proteins, and Biological Pathways Preventing Chromothripsis
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    Chapter 16 Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 17 Chromothripsis Detection and Characterization Using the CTLPScanner Web Server
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    Chapter 18 ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
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    Chapter 19 Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos
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    Chapter 20 Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
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    Chapter 21 Experimental Induction of Genome Chaos
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    Chapter 22 Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis
Attention for Chapter 21: Experimental Induction of Genome Chaos
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Chapter title
Experimental Induction of Genome Chaos
Chapter number 21
Book title
Chromothripsis
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7780-2_21
Pubmed ID
Book ISBNs
978-1-4939-7779-6, 978-1-4939-7780-2
Authors

Christine J. Ye, Guo Liu, Henry H. Heng, Ye, Christine J., Liu, Guo, Heng, Henry H.

Abstract

Genome chaos, or karyotype chaos, represents a powerful survival strategy for somatic cells under high levels of stress/selection. Since the genome context, not the gene content, encodes the genomic blueprint of the cell, stress-induced rapid and massive reorganization of genome topology functions as a very important mechanism for genome (karyotype) evolution. In recent years, the phenomenon of genome chaos has been confirmed by various sequencing efforts, and many different terms have been coined to describe different subtypes of the chaotic genome including "chromothripsis," "chromoplexy," and "structural mutations." To advance this exciting field, we need an effective experimental system to induce and characterize the karyotype reorganization process. In this chapter, an experimental protocol to induce chaotic genomes is described, following a brief discussion of the mechanism and implication of genome chaos in cancer evolution.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 30%
Student > Ph. D. Student 2 20%
Student > Bachelor 2 20%
Student > Master 1 10%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Biochemistry, Genetics and Molecular Biology 1 10%
Chemical Engineering 1 10%
Sports and Recreations 1 10%
Engineering 1 10%
Other 0 0%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2019.
All research outputs
#19,017,658
of 23,577,654 outputs
Outputs from Methods in molecular biology
#8,199
of 13,410 outputs
Outputs of similar age
#333,879
of 445,160 outputs
Outputs of similar age from Methods in molecular biology
#942
of 1,482 outputs
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