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Chromothripsis

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Cover of 'Chromothripsis'

Table of Contents

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    Book Overview
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    Chapter 1 The Genomic Characteristics and Origin of Chromothripsis
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    Chapter 2 Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
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    Chapter 3 Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
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    Chapter 4 Chromothripsis and the Macroevolution Theory
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    Chapter 5 Analysis of Chromothripsis by Combined FISH and Microarray Analysis
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    Chapter 6 Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
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    Chapter 7 Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
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    Chapter 8 Detection of Chromothripsis in Plants
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    Chapter 9 RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
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    Chapter 10 Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
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    Chapter 11 A Role for Retrotransposons in Chromothripsis
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    Chapter 12 Generation of Micronuclei and Detection of Chromosome Pulverization
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    Chapter 13 Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
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    Chapter 14 Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 15 Genes, Proteins, and Biological Pathways Preventing Chromothripsis
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    Chapter 16 Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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    Chapter 17 Chromothripsis Detection and Characterization Using the CTLPScanner Web Server
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    Chapter 18 ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
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    Chapter 19 Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Preimplantation Embryos
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    Chapter 20 Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
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    Chapter 21 Experimental Induction of Genome Chaos
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    Chapter 22 Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis
Attention for Chapter 16: Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
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Chapter title
Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
Chapter number 16
Book title
Chromothripsis
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7780-2_16
Pubmed ID
Book ISBNs
978-1-4939-7779-6, 978-1-4939-7780-2
Authors

Oumar Samassekou, Nathalie Bastien, Ju Yan, Sabine Mai, Régen Drouin, Samassekou, Oumar, Bastien, Nathalie, Yan, Ju, Mai, Sabine, Drouin, Régen

Abstract

We describe a method that assesses the impact of specific mutations of TP53 and genomic instability on gene expression of the most important genes involved in telomere length and structure homeostasis. The approaches consist of using a reverse transcriptase method and a quantitative PCR that were applied to isogenic cell lines from a colon cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 26%
Student > Bachelor 3 13%
Student > Master 3 13%
Student > Doctoral Student 1 4%
Professor 1 4%
Other 3 13%
Unknown 6 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 35%
Medicine and Dentistry 4 17%
Agricultural and Biological Sciences 1 4%
Veterinary Science and Veterinary Medicine 1 4%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 7 30%