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Rational Drug Design

Overview of attention for book
Cover of 'Rational Drug Design'

Table of Contents

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    Book Overview
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    Chapter 1 On Setting Up and Assessing Docking Simulations for Virtual Screening
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    Chapter 2 Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt Signaling
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    Chapter 3 Rational Design of Rho GTPase-Targeting Inhibitors
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    Chapter 4 Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies
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    Chapter 5 A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors.
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    Chapter 6 Identification of Allosteric Inhibitors of p21-Activated Kinase
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    Chapter 7 Using a Modified Yeast Two-Hybrid System to Screen for Chemical GEF Inhibitors
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    Chapter 8 Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening
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    Chapter 9 A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule Inhibitor
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    Chapter 10 Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1
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    Chapter 11 Affinity Purification of Protein Kinases that Adopt a Specific Inactive Conformation
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    Chapter 12 Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein Kinases
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    Chapter 13 Purification and Specific Assays for Measuring APE-1 Endonuclease Activity
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    Chapter 14 An In Vitro Screening to Identify Drug-Resistant Mutations for Target-Directed Chemotherapeutic Agents
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    Chapter 15 Utilizing AntagomiR (Antisense microRNA) to Knock Down microRNA in Murine Bone Marrow Cells
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    Chapter 16 Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs, and Other Therapeutics to Target Cells.
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    Chapter 17 Mouse models for tumor metastasis.
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Citations

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Title
Rational Drug Design
Published by
Humana Press, September 2012
DOI 10.1007/978-1-62703-008-3
ISBNs
978-1-62703-007-6, 978-1-62703-008-3
Editors

Zheng, Yi

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 29%
Student > Bachelor 2 12%
Researcher 2 12%
Professor 1 6%
Student > Ph. D. Student 1 6%
Other 1 6%
Unknown 5 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 29%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Agricultural and Biological Sciences 2 12%
Immunology and Microbiology 1 6%
Chemistry 1 6%
Other 0 0%
Unknown 6 35%