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Pharmaceutical Biotechnology

Overview of attention for book
Attention for Chapter 12: Applications of bacterial ghosts in biomedicine.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

twitter
1 tweeter
patent
4 patents

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
46 Mendeley
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Chapter title
Applications of bacterial ghosts in biomedicine.
Chapter number 12
Book title
Pharmaceutical Biotechnology
Published in
Advances in experimental medicine and biology, December 2008
DOI 10.1007/978-1-4419-1132-2_12
Pubmed ID
Book ISBNs
978-1-4419-1131-5, 978-1-4419-1132-2
Authors

Lubitz P, Mayr UB, Lubitz W, Petra Lubitz, Ulrike Beate Mayr, Werner Lubitz

Abstract

Bacterial Ghosts (BG) are empty cell envelopes of Gram-negative bacteria which have been produced by E-mediated lysis. BG are devoid of cytoplasmic content and in combination with the expression of the nuclease SNUC, BG are also devoid of chromosomal and plasmid DNA. Proof of concept and proof of principle studies showed that BG candidate vaccines are highly immunogenic and in many instances induce protective immunity against lethal challenge in animal models. Due to their nature of being bacterial envelope complexes, BG are endowed with intrinsic natural adjuvant activity. BG are able to stimulate the innate and adaptive immune system without any addition of exogenous adjuvants. Although the use of plasmid encoded genetic information is essential for the final make up of BG, BG are not to be considered as genetically manipulated organisms (GMO), as they are nonliving and devoid of genetic information. The latter aspect is of great importance for safety, as no pathogenic islands or antibiotic resistance cassettes can be transferred to other bacteria by horizontal gene transfer. This is an important difference to other chemical-, heat- and pressure- or radiation-inactivated vaccine candidates, which also very often need artificial adjuvants to be added to improve their immunogenicity. The final BG vaccine preparations are freeze dried and are stable for many years at ambient temperature. BG can also be used as carrier and delivery vehicles for drugs or active substances in tumor therapy and due to specific targeting of tumor cells allow a higher specificity of treatment and a reduction of the total amount of drug per application. As carrier of enzymatic activity BG can be used for a new concept of probiotics which can synthesise active compounds from substrates of the environment where they are applied with a certain preference for the gut system. Thus, BG represent a promising technology platform for novel vaccines including combination or DNA vaccines, as drug carriers for therapeutic approaches in tumor treatment and as novel probiotics.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Student > Master 7 15%
Researcher 6 13%
Student > Bachelor 5 11%
Professor 4 9%
Other 11 24%
Unknown 4 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 24%
Biochemistry, Genetics and Molecular Biology 7 15%
Medicine and Dentistry 5 11%
Engineering 3 7%
Veterinary Science and Veterinary Medicine 3 7%
Other 11 24%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2015.
All research outputs
#1,578,771
of 9,623,359 outputs
Outputs from Advances in experimental medicine and biology
#306
of 2,895 outputs
Outputs of similar age
#36,864
of 200,779 outputs
Outputs of similar age from Advances in experimental medicine and biology
#5
of 63 outputs
Altmetric has tracked 9,623,359 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,895 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.