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Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

Overview of attention for article published in BMC Cancer, March 2007
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
33 Mendeley
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Title
Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β
Published in
BMC Cancer, March 2007
DOI 10.1186/1471-2407-7-52
Pubmed ID
Authors

O Cristina Micali, Herman H Cheung, Stéphanie Plenchette, Sandra L Hurley, Peter Liston, Eric C LaCasse, Robert G Korneluk

Abstract

XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and -independent means. Loss of XAF1 expression through promoter methylation has been implicated in the process of tumorigenesis in a variety of cancers. In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
United Kingdom 1 3%
Korea, Republic of 1 3%
Unknown 30 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 8 24%
Other 4 12%
Student > Bachelor 2 6%
Student > Doctoral Student 2 6%
Other 6 18%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 48%
Medicine and Dentistry 7 21%
Biochemistry, Genetics and Molecular Biology 5 15%
Immunology and Microbiology 1 3%
Neuroscience 1 3%
Other 1 3%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#6,762,871
of 20,815,952 outputs
Outputs from BMC Cancer
#1,839
of 7,474 outputs
Outputs of similar age
#98,343
of 320,445 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
Altmetric has tracked 20,815,952 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,474 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them