↓ Skip to main content

Gene Therapy and Gene Delivery Systems

Overview of attention for book
Attention for Chapter 4: Nonviral Delivery of Cancer Genetic Vaccines
Altmetric Badge


4 Dimensions

Readers on

15 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Nonviral Delivery of Cancer Genetic Vaccines
Chapter number 4
Book title
Gene Therapy and Gene Delivery Systems
Published in
Advances in biochemical engineering biotechnology, January 2005
DOI 10.1007/10_004
Pubmed ID
Book ISBNs
978-3-54-028404-8, 978-3-54-032412-6

Little, Steven R., Langer, Robert, Steven R. Little, Robert Langer


The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review advances in the nonviral delivery of antigen-encoded plasmid DNA for the purpose of treating cancer through the human immune system, as this disease has drawn the most attention in this field to date. Brief overviews of dendritic cell immunobiology and the mechanism of immune activation through genetic vaccines set the stage for the desirability of delivery technology. Several promising nonviral delivery techniques are discussed along with a mention of targeting strategies aimed at improving the potency of vaccine formulations. Implications for the future of genetic vaccines are also presented.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 33%
Researcher 3 20%
Student > Master 3 20%
Professor > Associate Professor 2 13%
Professor 1 7%
Other 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 47%
Chemistry 4 27%
Engineering 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Other 0 0%