| Chapter title |
Nonviral Delivery of Cancer Genetic Vaccines
|
|---|---|
| Chapter number | 4 |
| Book title |
Gene Therapy and Gene Delivery Systems
|
| Published in |
Advances in biochemical engineering biotechnology, January 2005
|
| DOI | 10.1007/10_004 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-028404-8, 978-3-54-032412-6
|
| Authors |
Little, Steven R., Langer, Robert, Steven R. Little, Robert Langer |
| Abstract |
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review advances in the nonviral delivery of antigen-encoded plasmid DNA for the purpose of treating cancer through the human immune system, as this disease has drawn the most attention in this field to date. Brief overviews of dendritic cell immunobiology and the mechanism of immune activation through genetic vaccines set the stage for the desirability of delivery technology. Several promising nonviral delivery techniques are discussed along with a mention of targeting strategies aimed at improving the potency of vaccine formulations. Implications for the future of genetic vaccines are also presented. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 31% |
| Student > Master | 3 | 19% |
| Researcher | 3 | 19% |
| Professor > Associate Professor | 2 | 13% |
| Student > Bachelor | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 1 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 44% |
| Chemistry | 4 | 25% |
| Engineering | 2 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Other | 1 | 6% |