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Bacteriophages and Phage-Derived Proteins – Application Approaches

Overview of attention for article published in Current Medicinal Chemistry, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 2,251)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

twitter
22 tweeters
patent
2 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
68 Dimensions

Readers on

mendeley
265 Mendeley
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Title
Bacteriophages and Phage-Derived Proteins – Application Approaches
Published in
Current Medicinal Chemistry, April 2015
DOI 10.2174/0929867322666150209152851
Pubmed ID
Authors

Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska

Abstract

Currently, the bacterial resistance, especially to most commonly used antibiotics started to be a severe therapeutic problem. Nosocomial and community-acquired infections are usually caused by multidrug resistant strains. Therefore, we are forced to develop an alternative or supportive treatment for successful cure of life-threatening infections. The idea of using natural bacterial pathogens such as bacteriophages is already well known. Many papers have been published proving the high antibacterial efficacy of lytic phages tested in animal models as well as in the clinic. Researchers have also investigated the application of non-lytic phages and temperate phages, with promising results. Moreover, the development of molecular biology and novel generation methods of sequencing open up new possibilities in the design of engineered phages and recombinant phage-derived proteins. Encouraging performances were noted especially for phage enzymes involved in the first step of viral infection responsible for bacterial envelope degradation, named depolymerases. There are at least five major groups of such enzymes - peptidoglycan hydrolases, endosialidases, endorhamnosidases, alginate lyases and hyaluronate lyases - that have application potential. There is also much interest in proteins encoded by lysis cassette genes (holins, endolysins, spanins) responsible for progeny release during the phage lytic cycle. In this review, we discuss several issues of phage and phage-derived protein application approaches in therapy, diagnostics and biotechnology in general.

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 265 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 <1%
Spain 1 <1%
Nepal 1 <1%
United States 1 <1%
Unknown 261 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 66 25%
Student > Ph. D. Student 47 18%
Student > Bachelor 45 17%
Researcher 27 10%
Professor > Associate Professor 15 6%
Other 28 11%
Unknown 37 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 72 27%
Biochemistry, Genetics and Molecular Biology 69 26%
Immunology and Microbiology 36 14%
Medicine and Dentistry 10 4%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 26 10%
Unknown 45 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2019.
All research outputs
#771,046
of 14,860,150 outputs
Outputs from Current Medicinal Chemistry
#22
of 2,251 outputs
Outputs of similar age
#16,582
of 285,425 outputs
Outputs of similar age from Current Medicinal Chemistry
#1
of 49 outputs
Altmetric has tracked 14,860,150 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,251 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.