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Metabolic engineering of microorganisms: general strategies and drug production

Overview of attention for article published in Drug Discovery Today, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
88 Dimensions

Readers on

mendeley
296 Mendeley
citeulike
2 CiteULike
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Title
Metabolic engineering of microorganisms: general strategies and drug production
Published in
Drug Discovery Today, January 2009
DOI 10.1016/j.drudis.2008.08.004
Pubmed ID
Authors

Sang Yup Lee, Hyun Uk Kim, Jin Hwan Park, Jong Myung Park, Tae Yong Kim

Abstract

Rac is a protein involved in the various functions of macrophages (Mphi), including the production of reactive oxygen species (ROS), phagocytosis, chemotaxis and the secretion of cytokines (such as gamma-INF). This study tested the effects of nucleosides containing 8-oxoguanine(8-hydroxyguanine) such as 8-oxo-2'-guanosine (8-oxoG) or 8-oxo-2'-deoxyguanosine (8-oxodG), on Rac and the above-listed Rac-associated functions of Mphi using mouse peritoneal Mphi (MpMphi). It is reported that 8-oxodG was able to effectively inhibit Rac and the Rac-associated functions of MpMphi. Compared to 8-oxodG, 8-oxoG showed negligible effects. Furthermore, normal nucleosides such as deoxyguanosine (dG), guanosine (G) and adenosine (A) did not exert any effects. These results suggest that 8-oxodG could be used as a potential tool to modulate the functions of Mphi that are intimately related to various pathological processes.

Mendeley readers

The data shown below were compiled from readership statistics for 296 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
Germany 3 1%
Brazil 3 1%
Denmark 3 1%
Austria 2 <1%
Netherlands 2 <1%
India 2 <1%
Belgium 1 <1%
France 1 <1%
Other 9 3%
Unknown 264 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 30%
Researcher 67 23%
Student > Master 38 13%
Student > Bachelor 25 8%
Student > Postgraduate 18 6%
Other 60 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 176 59%
Biochemistry, Genetics and Molecular Biology 36 12%
Chemistry 20 7%
Engineering 19 6%
Unspecified 13 4%
Other 32 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#2,137,521
of 12,380,517 outputs
Outputs from Drug Discovery Today
#351
of 1,685 outputs
Outputs of similar age
#73,301
of 276,166 outputs
Outputs of similar age from Drug Discovery Today
#13
of 39 outputs
Altmetric has tracked 12,380,517 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,685 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.