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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury
|
|---|---|
| Published in |
Science Advances, April 2018
|
| DOI | 10.1126/sciadv.aaq0597 |
| Pubmed ID | |
| Authors |
Isma Liza Mohd Isa, Sunny A. Abbah, Michelle Kilcoyne, Daisuke Sakai, Peter Dockery, David P. Finn, Abhay Pandit |
| Abstract |
Painful intervertebral disc degeneration is mediated by inflammation that modulates glycosylation and induces hyperinnervation and sensory sensitization, which result in discogenic pain. Hyaluronic acid (HA) used as a therapeutic biomaterial can reduce inflammation and pain, but the effects of HA therapy on glycosylation and pain associated with disc degeneration have not been previously determined. We describe a novel rat model of pain induced by intervertebral disc injury, with validation of the pain phenotype by morphine treatment. Using this model, we assessed the efficacy of HA hydrogel for the alleviation of pain, demonstrating that it reduced nociceptive behavior, an effect associated with down-regulation of nociception markers and inhibition of hyperinnervation. Furthermore, HA hydrogel altered glycosylation and modulated key inflammatory and regulatory signaling pathways, resulting in attenuation of inflammation and regulation of matrix components. Our results suggest that HA hydrogel is a promising clinical candidate for the treatment of back pain caused by degenerated discs. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 3 | 27% |
| United States | 3 | 27% |
| United Kingdom | 1 | 9% |
| Portugal | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Scientists | 3 | 27% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 108 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 20% |
| Researcher | 16 | 15% |
| Student > Bachelor | 7 | 6% |
| Student > Master | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 12 | 11% |
| Unknown | 40 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 9% |
| Engineering | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Agricultural and Biological Sciences | 8 | 7% |
| Materials Science | 6 | 6% |
| Other | 20 | 19% |
| Unknown | 45 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#5,213,149
of 25,382,440 outputs
Outputs from Science Advances
#9,333
of 12,215 outputs
Outputs of similar age
#94,307
of 342,873 outputs
Outputs of similar age from Science Advances
#180
of 239 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,215 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 120.3. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,873 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 239 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.