Title |
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer
|
---|---|
Published in |
The Prostate, February 2015
|
DOI | 10.1002/pros.22954 |
Pubmed ID | |
Authors |
Suyin Paulynn Chin, James R. Marthick, Alison C. West, Annabel K. Short, Jyoti Chuckowree, Andrea M. Polanowski, Russell J. Thomson, Adele F. Holloway, Joanne L. Dickinson |
Abstract |
Integrin alpha2 beta1 (α2 β1 ) plays an integral role in tumour cell invasion, metastasis and angiogenesis, and altered expression of the receptor has been linked to tumour prognosis in several solid tumours. However, the relationship is complex, with both increased and decreased expression associated with different stages of tumour metastases in several tumour types. The ITGA2 gene, which codes for the α2 subunit, was examined to investigate whether a large CpG island associated with its promoter region is involved in the differential expression of ITGA2 observed in prostate cancer. |
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