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New genetic loci link adipose and insulin biology to body fat distribution

Overview of attention for article published in Nature, February 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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30 news outlets
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7 blogs
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187 tweeters
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1 weibo user
facebook
14 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
619 Dimensions

Readers on

mendeley
1045 Mendeley
citeulike
4 CiteULike
Title
New genetic loci link adipose and insulin biology to body fat distribution
Published in
Nature, February 2015
DOI 10.1038/nature14132
Pubmed ID
Authors

Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-Costa, Tamara S. Roman, Alexander W. Drong, Ci Song, Stefan Gustafsson, Felix R. Day, Tonu Esko, Tove Fall, Zoltán Kutalik, Jian’an Luan, Joshua C. Randall, André Scherag, Sailaja Vedantam, Andrew R. Wood, Jin Chen, Rudolf Fehrmann, Juha Karjalainen, Bratati Kahali, Ching-Ti Liu, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Georg B. Ehret, Mary F. Feitosa, Anuj Goel, Anne U. Jackson, Toby Johnson, Marcus E. Kleber, Kati Kristiansson, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Alena Stančáková, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Jana V. Van Vliet-Ostaptchouk, Loïc Yengo, Weihua Zhang, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Stefan Böhringer, Fabrice Bonnet, Yvonne Böttcher, Marcel Bruinenberg, Delia B. Carba, Ida H. Caspersen, Robert Clarke, E. Warwick Daw, Joris Deelen, Ewa Deelman, Graciela Delgado, Alex S. F. Doney, Niina Eklund, Michael R. Erdos, Karol Estrada, Elodie Eury, Nele Friedrich, Melissa E. Garcia, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Jagvir Grewal, Christopher J. Groves, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Kauko Heikkilä, Karl-Heinz Herzig, Quinta Helmer, Hans L. Hillege, Oddgeir Holmen, Steven C. Hunt, Aaron Isaacs, Till Ittermann, Alan L. James, Ingegerd Johansson, Thorhildur Juliusdottir, Ioanna-Panagiota Kalafati, Leena Kinnunen, Wolfgang Koenig, Ishminder K. Kooner, Wolfgang Kratzer, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Rebecca Mills, Alireza Moayyeri, Keri L. Monda, Simon P. Mooijaart, Thomas W. Mühleisen, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Ramaiah Nagaraja, Michael A. Nalls, Narisu, Nicola Glorioso, Ilja M. Nolte, Matthias Olden, Nigel W. Rayner, Frida Renstrom, Janina S. Ried, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Bengt Sennblad, Thomas Seufferlein, Colleen M. Sitlani, Albert Vernon Smith, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Andreas Tomaschitz, Chiara Troffa, Floor V. A. van Oort, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Roman Wennauer, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Qunyuan Zhang, Jing Hua Zhao, Eoin P. Brennan, Murim Choi, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, Ali G. Gharavi, Åsa K. Hedman, Marie-France Hivert, Jinyan Huang, Stavroula Kanoni, Fredrik Karpe, Sarah Keildson, Krzysztof Kiryluk, Liming Liang, Richard P. Lifton, Baoshan Ma, Amy J. McKnight, Ruth McPherson, Andres Metspalu, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, George Nicholson, Dale R. Nyholt, Christian Olsson, John R. B. Perry, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Eric E. Schadt, Robert A. Scott, Lisette Stolk, Edgar E. Vallejo, Harm-Jan Westra, Krina T. Zondervan, Philippe Amouyel, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Morris J. Brown, Michel Burnier, Harry Campbell, Aravinda Chakravarti, Peter S. Chines, Simone Claudi-Boehm, Francis S. Collins, Dana C. Crawford, John Danesh, Ulf de Faire, Eco J. C. de Geus, Marcus Dörr, Raimund Erbel, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Christian Gieger, Vilmundur Gudnason, Christopher A. Haiman, Tamara B. Harris, Andrew T. Hattersley, Markku Heliövaara, Andrew A. Hicks, Aroon D. Hingorani, Wolfgang Hoffmann, Albert Hofman, Georg Homuth, Steve E. Humphries, Elina Hyppönen, Thomas Illig, Marjo-Riitta Jarvelin, Berit Johansen, Pekka Jousilahti, Antti M. Jula, Jaakko Kaprio, Frank Kee, Sirkka M. Keinanen-Kiukaanniemi, Jaspal S. Kooner, Charles Kooperberg, Peter Kovacs, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loic Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Arthur W. Musk, Stefan Möhlenkamp, Andrew D. Morris, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Lyle J. Palmer, Brenda W. Penninx, Annette Peters, Peter P. Pramstaller, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Paul M. Ridker, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Peter E. H. Schwarz, Alan R. Shuldiner, Jan A. Staessen, Valgerdur Steinthorsdottir, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, Angelo Tremblay, Elena Tremoli, Marie-Claude Vohl, Uwe Völker, Peter Vollenweider, James F. Wilson, Jacqueline C. Witteman, Linda S. Adair, Murielle Bochud, Bernhard O. Boehm, Stefan R. Bornstein, Claude Bouchard, Stéphane Cauchi, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Richard S. Cooper, George Dedoussis, Luigi Ferrucci, Philippe Froguel, Hans-Jörgen Grabe, Anders Hamsten, Jennie Hui, Kristian Hveem, Karl-Heinz Jöckel, Mika Kivimaki, Diana Kuh, Markku Laakso, Yongmei Liu, Winfried März, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N. A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Pérusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo E. Saaristo, Danish Saleheen, Juha Sinisalo, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Thorsteinsdottir, Michael Stumvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Giovanni Veronesi, Mark Walker, Nicholas J. Wareham, Hugh Watkins, H-Erich Wichmann, Goncalo R. Abecasis, Themistocles L. Assimes, Sonja I. Berndt, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Lude Franke, Timothy M. Frayling, Leif C. Groop, David J. Hunter, Robert C. Kaplan, Jeffrey R. O’Connell, Lu Qi, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Cristen J. Willer, Peter M. Visscher, Jian Yang, Joel N. Hirschhorn, M. Carola Zillikens, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Caroline S. Fox, Inês Barroso, Paul W. Franks, Erik Ingelsson, Iris M. Heid, Ruth J. F. Loos, L. Adrienne Cupples, Andrew P. Morris, Cecilia M. Lindgren, Karen L Mohlke

Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 1,045 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 1%
Germany 8 <1%
Netherlands 4 <1%
United Kingdom 4 <1%
Norway 3 <1%
Sweden 2 <1%
Ireland 2 <1%
Austria 1 <1%
Denmark 1 <1%
Other 13 1%
Unknown 994 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 253 24%
Student > Ph. D. Student 219 21%
Student > Master 119 11%
Student > Bachelor 77 7%
Unspecified 77 7%
Other 299 29%
Unknown 1 <1%
Readers by discipline Count As %
Agricultural and Biological Sciences 264 25%
Medicine and Dentistry 247 24%
Biochemistry, Genetics and Molecular Biology 201 19%
Unspecified 130 12%
Nursing and Health Professions 34 3%
Other 168 16%
Unknown 1 <1%

Attention Score in Context

This research output has an Altmetric Attention Score of 360. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2018.
All research outputs
#32,055
of 13,846,610 outputs
Outputs from Nature
#3,574
of 70,685 outputs
Outputs of similar age
#639
of 282,452 outputs
Outputs of similar age from Nature
#123
of 926 outputs
Altmetric has tracked 13,846,610 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,685 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 77.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 926 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.