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Mendeley readers
Attention Score in Context
| Title |
Alternative splicing regulation by interaction of phosphatase PP2Cγ with nucleic acid–binding protein YB-1
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, June 2007
|
| DOI | 10.1038/nsmb1257 |
| Pubmed ID | |
| Authors |
Eric Allemand, Michelle L Hastings, Michael V Murray, Michael P Myers, Adrian R Krainer |
| Abstract |
Kinases and phosphatases participate in precursor messenger RNA (pre-mRNA) splicing regulation, but their precise roles and the identities of their cofactors and substrates remain poorly understood. The human Ser/Thr phosphatase PP2Cgamma promotes spliceosome assembly. We show that PP2Cgamma's distinctive acidic domain is essential for its activity in splicing and interacts with YB-1, a spliceosome-associated factor. Moreover, PP2Cgamma is a phosphoprotein in vivo, and its acidic domain is phosphorylated under splicing conditions in vitro. PP2Cgamma phosphorylation enhances its interaction with YB-1 and is reversed by the phosphatase in cis. PP2Cgamma knockdown leaves constitutive splicing unaffected but inhibits cell proliferation and affects alternative splicing of CD44, a YB-1 target. This effect on splicing regulation is mediated by PP2Cgamma's acidic domain, which is essential to promote inclusion of CD44 exons v4 and v5 in vivo. We propose that PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Argentina | 1 | 2% |
| Unknown | 49 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 39% |
| Student > Ph. D. Student | 11 | 22% |
| Student > Master | 5 | 10% |
| Professor | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 51% |
| Biochemistry, Genetics and Molecular Biology | 15 | 29% |
| Medicine and Dentistry | 3 | 6% |
| Sports and Recreations | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 5 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2008.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Nature Structural & Molecular Biology
#2,602
of 4,186 outputs
Outputs of similar age
#28,956
of 80,149 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#17
of 30 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 80,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.