Title |
Accurate microRNA target prediction correlates with protein repression levels
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Published in |
BMC Bioinformatics, September 2009
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DOI | 10.1186/1471-2105-10-295 |
Pubmed ID | |
Authors |
Manolis Maragkakis, Panagiotis Alexiou, Giorgio L Papadopoulos, Martin Reczko, Theodore Dalamagas, George Giannopoulos, George Goumas, Evangelos Koukis, Kornilios Kourtis, Victor A Simossis, Praveen Sethupathy, Thanasis Vergoulis, Nectarios Koziris, Timos Sellis, Panagiotis Tsanakas, Artemis G Hatzigeorgiou |
Abstract |
MicroRNAs are small endogenously expressed non-coding RNA molecules that regulate target gene expression through translation repression or messenger RNA degradation. MicroRNA regulation is performed through pairing of the microRNA to sites in the messenger RNA of protein coding genes. Since experimental identification of miRNA target genes poses difficulties, computational microRNA target prediction is one of the key means in deciphering the role of microRNAs in development and disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 4 | 2% |
United States | 4 | 2% |
China | 3 | 1% |
Italy | 3 | 1% |
Malaysia | 2 | <1% |
Switzerland | 2 | <1% |
Mexico | 2 | <1% |
Hong Kong | 1 | <1% |
Austria | 1 | <1% |
Other | 8 | 3% |
Unknown | 207 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 70 | 30% |
Researcher | 59 | 25% |
Student > Master | 29 | 12% |
Student > Doctoral Student | 17 | 7% |
Professor > Associate Professor | 17 | 7% |
Other | 32 | 14% |
Unknown | 13 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 125 | 53% |
Biochemistry, Genetics and Molecular Biology | 41 | 17% |
Computer Science | 23 | 10% |
Medicine and Dentistry | 15 | 6% |
Engineering | 4 | 2% |
Other | 13 | 5% |
Unknown | 16 | 7% |