Chapter title |
Structure of toll-like receptors.
|
---|---|
Chapter number | 9 |
Book title |
Toll-Like Receptors (TLRs) and Innate Immunity
|
Published in |
Handbook of experimental pharmacology, January 2008
|
DOI | 10.1007/978-3-540-72167-3_9 |
Pubmed ID | |
Book ISBNs |
978-3-54-072166-6, 978-3-54-072167-3
|
Authors |
Gay, Nicholas J, Gangloff, Monique, Gay, Nicholas J., Nicholas J. Gay, Monique Gangloff |
Abstract |
The ten human Toll-like receptors are able to respond to an extremely diverse range of microbial products ranging from di- and tri-acylated lipids to nucleic acids. An understanding of the molecular structure adopted by the receptor extracellular, transmembrane, and cytoplasmic domains and the way in which these structures interact with ligands and downstream signaling adapters can explain how recognition and signal transduction are achieved at a molecular level. In this article we discuss how the leucine-rich repeats of the receptor ectodomain have evolved to bind a wide variety of biological molecules. We also discuss how ligand binding induces dimerization of two receptor chains and initiates a series of protein conformational changes that lead to a signaling event in the cytoplasm of the immune system cell. Thus, the signaling process of the TLRs can be viewed as a unidirectional molecular switch. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 6% |
Belgium | 1 | 3% |
Unknown | 28 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 35% |
Student > Ph. D. Student | 5 | 16% |
Professor > Associate Professor | 3 | 10% |
Professor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 16% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 48% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Medicine and Dentistry | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Physics and Astronomy | 1 | 3% |
Other | 3 | 10% |
Unknown | 4 | 13% |