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Sirtuins

Overview of attention for book
Cover of 'Sirtuins'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction: sirtuins in aging and diseases.
  3. Altmetric Badge
    Chapter 2 Sirtuins in Yeast: Phenotypes and Tools
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    Chapter 3 C. elegans Sirtuins.
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    Chapter 4 Genetic and Biochemical Tools for Investigating Sirtuin Function in Drosophila melanogaster.
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    Chapter 5 Generating Mammalian sirtuin tools for protein-interaction analysis.
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    Chapter 6 Mass spectrometry-based detection of protein acetylation.
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    Chapter 7 SILAC-Based Quantification of Sirt1-Responsive Lysine Acetylome.
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    Chapter 8 Targeted Quantitation of Acetylated Lysine Peptides by Selected Reaction Monitoring Mass Spectrometry
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    Chapter 9 Identification of deacetylase substrates with the biotin switch approach.
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    Chapter 10 Assaying Chromatin Sirtuins
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    Chapter 11 Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.
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    Chapter 12 Detecting Sirtuin-Catalyzed Deacylation Reactions Using 32 P-Labeled NAD and Thin-Layer Chromatography
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    Chapter 13 Chemical Acetylation and Deacetylation
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    Chapter 14 Accurate Measurement of Nicotinamide Adenine Dinucleotide (NAD + ) with High-Performance Liquid Chromatography
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    Chapter 15 In Vivo Measurement of the Acetylation State of Sirtuin Substrates as a Proxy for Sirtuin Activity
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    Chapter 16 Oxygen flux analysis to understand the biological function of sirtuins.
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    Chapter 17 The Emerging Links Between Sirtuins and Autophagy
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    Chapter 18 Methods to Study the Role of Sirtuins in Genome Stability
  20. Altmetric Badge
    Chapter 19 Circadian Measurements of Sirtuin Biology
  21. Altmetric Badge
    Chapter 20 Utilizing Calorie Restriction to Evaluate the Role of Sirtuins in Healthspan and Lifespan of Mice
  22. Altmetric Badge
    Chapter 21 Erratum: Sirtuins: Methods and Protocols
Attention for Chapter 1: Introduction: sirtuins in aging and diseases.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

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1 blog

Citations

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3 Dimensions

Readers on

mendeley
38 Mendeley
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Chapter title
Introduction: sirtuins in aging and diseases.
Chapter number 1
Book title
Sirtuins
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-637-5_1
Pubmed ID
Book ISBNs
978-1-62703-636-8, 978-1-62703-637-5
Authors

Leonard Guarente

Abstract

Over the past 15 years, the number of papers published on sirtuins has exploded. The initial link between sirtuins and aging comes from studies in yeast, in which it was shown that the life span of yeast mother cells (replicative aging) was proportional to the SIR2 gene dosage. Subsequent studies have shown that SIR2 homologs also slow aging in C. elegans, Drosophila, and mice. An important insight into the function of sirtuins came from the finding that yeast Sir2p and mammalian SIRT1 are NAD(+)-dependent protein deacetylases. In mammals, there are seven sirtuins (SIRT1-7). Their functions do not appear to be redundant, in part because three are primarily nuclear (SIRT1, 6, and 7), three are mitochondrial (SIRT3, 4, and 5), and one is cytoplasmic (SIRT2). The past decade has provided an avalanche of data showing deacetylation of many key transcription factors. In this chapter, I will address the evidence that sirtuins mediate the effects of CR on physiology and will then turn to the evidence of a relationship between sirtuins and aging and life span. Finally, I will discuss the roles of sirtuins in diseases of aging and the prospects of translating these findings to novel therapeutic strategies to treat major diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Portugal 1 3%
Unknown 36 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Student > Master 7 18%
Student > Ph. D. Student 6 16%
Student > Bachelor 2 5%
Professor > Associate Professor 2 5%
Other 3 8%
Unknown 10 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 18%
Biochemistry, Genetics and Molecular Biology 5 13%
Medicine and Dentistry 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Chemistry 2 5%
Other 7 18%
Unknown 10 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2013.
All research outputs
#3,748,714
of 23,577,654 outputs
Outputs from Methods in molecular biology
#907
of 13,410 outputs
Outputs of similar age
#38,879
of 284,930 outputs
Outputs of similar age from Methods in molecular biology
#30
of 336 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,410 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 336 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.