Title |
Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker
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Published in |
BMC Cancer, March 2003
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DOI | 10.1186/1471-2407-3-6 |
Pubmed ID | |
Authors |
Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño, Angel Pestaña |
Abstract |
RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search for RAD54L mutations in 29 menigiomas with allelic deletions in 1p, the only genetic change observed was a silent C/T transition at nucleotide 2290 in exon 18. In this communication the possible association of the 2290C/T polymorphism with the risk of meningiomas was examined. In addition, the usefulness of this polymorphism as a genetic marker within the meningioma consensus deletion region in 1p32 was also verified. The present study comprises 287 blood control samples and 70 meningiomas from Spain and Ecuador. Matched blood samples were only available from Spanish patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 21% |
Researcher | 5 | 21% |
Student > Ph. D. Student | 4 | 17% |
Professor > Associate Professor | 2 | 8% |
Unspecified | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 29% |
Biochemistry, Genetics and Molecular Biology | 6 | 25% |
Medicine and Dentistry | 3 | 13% |
Business, Management and Accounting | 1 | 4% |
Unspecified | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 21% |