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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Synthesis from DNA of a molecule with the connectivity of a cube
|
|---|---|
| Published in |
Nature, April 1991
|
| DOI | 10.1038/350631a0 |
| Pubmed ID | |
| Authors |
Junghuei Chen, Nadrian C. Seeman |
| Abstract |
A principal goal of biotechnology is the assembly of novel biomaterials for analytical, industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched junctions makes DNA a good candidate for building frameworks to which proteins or other functional molecules can be attached and thereby juxtaposed. The addition of single-stranded 'sticky' ends to branched DNA molecules converts them into macromolecular valence clusters that can be ligated together. The edges of these frameworks are double-helical DNA, and the vertices correspond to the branch points of junctions. Here, we report the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices. Each of the six 'faces' of the object is a single-stranded cyclic molecule, doubly catenated to four neighbouring strands, and each vertex is connected by an edge to three others. Each edge contains a unique restriction site for analytical purposes. This is the first construction of a closed polyhedral object from DNA. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 33% |
| United States | 2 | 22% |
| United Kingdom | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Scientists | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 577 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 2% |
| Germany | 5 | <1% |
| United Kingdom | 4 | <1% |
| France | 2 | <1% |
| Norway | 1 | <1% |
| Israel | 1 | <1% |
| Denmark | 1 | <1% |
| Hungary | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 551 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 169 | 29% |
| Student > Master | 90 | 16% |
| Student > Bachelor | 66 | 11% |
| Researcher | 64 | 11% |
| Student > Doctoral Student | 31 | 5% |
| Other | 70 | 12% |
| Unknown | 87 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 153 | 27% |
| Biochemistry, Genetics and Molecular Biology | 77 | 13% |
| Agricultural and Biological Sciences | 71 | 12% |
| Physics and Astronomy | 62 | 11% |
| Engineering | 42 | 7% |
| Other | 77 | 13% |
| Unknown | 95 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#1,020,193
of 25,353,525 outputs
Outputs from Nature
#32,154
of 97,360 outputs
Outputs of similar age
#141
of 17,371 outputs
Outputs of similar age from Nature
#6
of 189 outputs
Altmetric has tracked 25,353,525 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 97,360 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 17,371 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 189 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.