Report for: Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation

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Title	Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation
Published in	Cancer Research, April 2004
DOI	10.1158/0008-5472.can-04-0649
Pubmed ID	15087373
Authors	Sang Eun Park, Nam Deuk Kim, Young Hyun Yoo
Abstract	Although a recent study (Zhang et al. Cell Death Differ 2002; 9; 790-800) presented that acetylcholinesterase (AChE) might be an important common component in leading to various types of apoptosis, the molecular mechanism, by which AChE functions, had remained elusive before that study. We explored the role of AChE in apoptosis by silencing the AChE gene. Silencing of the AChE gene abolished the expression of AChE and prevented caspase-9 activation, decrease of cell viability, nuclear condensation and poly(adenosine diphosphate-ribose) polymerase cleavage but not mitochondrial events. Importantly, silencing of the AChE gene blocked the interaction between apoptotic protease-activating factor-1 and cytochrome c. Here we propose that AChE plays a pivotal role in the formation of apoptosome.

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Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Iran, Islamic Republic of	1	2%
Unknown	48	98%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	8	16%
Student > Master	6	12%
Student > Bachelor	5	10%
Researcher	4	8%
Student > Doctoral Student	3	6%
Other	9	18%
Unknown	14	29%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	10	20%
Agricultural and Biological Sciences	9	18%
Medicine and Dentistry	4	8%
Neuroscience	4	8%
Pharmacology, Toxicology and Pharmaceutical Science	3	6%
Other	8	16%
Unknown	11	22%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2022.

All research outputs

#2,334,673

of 23,206,358 outputs

Outputs from Cancer Research

#1,770

of 17,986 outputs

Outputs of similar age

#3,395

of 58,439 outputs

Outputs of similar age from Cancer Research

#10

of 204 outputs

Altmetric has tracked 23,206,358 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 17,986 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 89% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,439 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.

We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.

Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation

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Geographical breakdown

Demographic breakdown

Attention Score in Context