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Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation

Overview of attention for article published in Cancer Research, April 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
patent
2 patents

Citations

dimensions_citation
122 Dimensions

Readers on

mendeley
49 Mendeley
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Title
Acetylcholinesterase Plays a Pivotal Role in Apoptosome Formation
Published in
Cancer Research, April 2004
DOI 10.1158/0008-5472.can-04-0649
Pubmed ID
Authors

Sang Eun Park, Nam Deuk Kim, Young Hyun Yoo

Abstract

Although a recent study (Zhang et al. Cell Death Differ 2002; 9; 790-800) presented that acetylcholinesterase (AChE) might be an important common component in leading to various types of apoptosis, the molecular mechanism, by which AChE functions, had remained elusive before that study. We explored the role of AChE in apoptosis by silencing the AChE gene. Silencing of the AChE gene abolished the expression of AChE and prevented caspase-9 activation, decrease of cell viability, nuclear condensation and poly(adenosine diphosphate-ribose) polymerase cleavage but not mitochondrial events. Importantly, silencing of the AChE gene blocked the interaction between apoptotic protease-activating factor-1 and cytochrome c. Here we propose that AChE plays a pivotal role in the formation of apoptosome.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 16%
Student > Master 6 12%
Student > Bachelor 5 10%
Researcher 4 8%
Student > Doctoral Student 3 6%
Other 9 18%
Unknown 14 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 20%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 4 8%
Neuroscience 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 8 16%
Unknown 11 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2022.
All research outputs
#2,278,207
of 22,774,233 outputs
Outputs from Cancer Research
#1,734
of 17,867 outputs
Outputs of similar age
#3,311
of 57,966 outputs
Outputs of similar age from Cancer Research
#10
of 204 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.