Title |
Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthritis
|
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Published in |
Arthritis Research & Therapy, October 2004
|
DOI | 10.1186/ar1444 |
Pubmed ID | |
Authors |
Sarah L Gaffen |
Abstract |
IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced primarily by T cells, particularly those of the memory compartment. In contrast, IL-17 receptor is ubiquitously expressed, making nearly all cells potential targets of IL-17. Although it has only limited homology to other cytokines, IL-17 exhibits proinflammatory properties similar to those of tumor necrosis factor-alpha, particularly with respect to induction of other inflammatory effectors. In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 3% |
United States | 2 | 3% |
Japan | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 65 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 27% |
Student > Ph. D. Student | 13 | 18% |
Student > Master | 12 | 17% |
Student > Doctoral Student | 7 | 10% |
Other | 3 | 4% |
Other | 9 | 13% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 27% |
Agricultural and Biological Sciences | 16 | 23% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 9 | 13% |
Unknown | 9 | 13% |