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Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

Overview of attention for article published in Cell, February 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
2 blogs
twitter
3 tweeters
weibo
5 weibo users
facebook
5 Facebook pages

Citations

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149 Dimensions

Readers on

mendeley
235 Mendeley
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Title
Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
Published in
Cell, February 2015
DOI 10.1016/j.cell.2015.01.034
Pubmed ID
Authors

Carlos T. Pineda, Saumya Ramanathan, Klementina Fon Tacer, Jenny L. Weon, Malia B. Potts, Yi-Hung Ou, Michael A. White, Patrick Ryan Potts

Abstract

AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic processes to regain energy homeostasis. Cancer cells can occasionally suppress the growth-restrictive AMPK pathway by mutation of an upstream regulatory kinase. Here, we describe a widespread mechanism to suppress AMPK through its ubiquitination and degradation by the cancer-specific MAGE-A3/6-TRIM28 ubiquitin ligase. MAGE-A3 and MAGE-A6 are highly similar proteins normally expressed only in the male germline but frequently re-activated in human cancers. MAGE-A3/6 are necessary for cancer cell viability and are sufficient to drive tumorigenic properties of non-cancerous cells. Screening for targets of MAGE-A3/6-TRIM28 revealed that it ubiquitinates and degrades AMPKα1. This leads to inhibition of autophagy, activation of mTOR signaling, and hypersensitization to AMPK agonists, such as metformin. These findings elucidate a germline mechanism commonly hijacked in cancer to suppress AMPK.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Canada 2 <1%
United Kingdom 1 <1%
Sweden 1 <1%
Japan 1 <1%
Germany 1 <1%
Unknown 225 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 25%
Researcher 33 14%
Student > Master 24 10%
Student > Bachelor 21 9%
Professor > Associate Professor 17 7%
Other 52 22%
Unknown 30 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 81 34%
Agricultural and Biological Sciences 70 30%
Medicine and Dentistry 28 12%
Arts and Humanities 4 2%
Chemistry 4 2%
Other 10 4%
Unknown 38 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2019.
All research outputs
#954,633
of 15,149,790 outputs
Outputs from Cell
#3,438
of 15,055 outputs
Outputs of similar age
#20,123
of 287,716 outputs
Outputs of similar age from Cell
#86
of 142 outputs
Altmetric has tracked 15,149,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,055 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,716 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.