Title |
Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes
|
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Published in |
Virology Journal, August 2006
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DOI | 10.1186/1743-422x-3-58 |
Pubmed ID | |
Authors |
Rosa M Dalton, Anne E Mullin, Maria Joao Amorim, Elizabeth Medcalf, Laurence S Tiley, Paul Digard |
Abstract |
The RNA-dependent RNA polymerase of Influenza A virus is a determinant of viral pathogenicity and host range that is responsible for transcribing and replicating the negative sense segmented viral genome (vRNA). Transcription produces capped and polyadenylated mRNAs whereas genome replication involves the synthesis of an alternative plus-sense transcript (cRNA) with unmodified termini that is copied back to vRNA. Viral mRNA transcription predominates at early stages of viral infection, while later, negative sense genome replication is favoured. However, the "switch" that regulates the transition from transcription to replication is poorly understood. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 17% |
Sierra Leone | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
United States | 1 | 2% |
Russia | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 62 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 38% |
Researcher | 12 | 18% |
Professor | 4 | 6% |
Student > Bachelor | 4 | 6% |
Unspecified | 3 | 5% |
Other | 10 | 15% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 39% |
Biochemistry, Genetics and Molecular Biology | 9 | 14% |
Immunology and Microbiology | 7 | 11% |
Medicine and Dentistry | 6 | 9% |
Unspecified | 3 | 5% |
Other | 5 | 8% |
Unknown | 10 | 15% |