| Chapter title |
Epstein–Barr Virus Strain Variation
|
|---|---|
| Chapter number | 4 |
| Book title |
Epstein Barr Virus Volume 1
|
| Published in |
Current topics in microbiology and immunology, January 2015
|
| DOI | 10.1007/978-3-319-22822-8_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922821-1, 978-3-31-922822-8
|
| Authors |
Paul J. Farrell, Farrell, Paul J. |
| Abstract |
What is wild-type Epstein-Barr virus and are there genetic differences in EBV strains that contribute to some of the EBV-associated diseases? Recent progress in DNA sequencing has resulted in many new Epstein-Barr virus (EBV) genome sequences becoming available. EBV isolates worldwide can be grouped into type 1 and type 2, a classification based on the EBNA2 gene sequence. Type 1 transforms human B cells into lymphoblastoid cell lines much more efficiently than type 2 EBV and molecular mechanisms that may account for this difference in cell transformation are now becoming understood. Study of geographic variation of EBV strains independent of the type 1/type 2 classification and systematic investigation of the relationship between viral strains, infection and disease are now becoming possible. So we should consider more directly whether viral sequence variation might play a role in the incidence of some EBV-associated diseases. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 18% |
| Student > Bachelor | 8 | 14% |
| Student > Ph. D. Student | 4 | 7% |
| Researcher | 3 | 5% |
| Student > Postgraduate | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 19 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Agricultural and Biological Sciences | 5 | 9% |
| Immunology and Microbiology | 3 | 5% |
| Nursing and Health Professions | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 21 | 37% |