Title |
Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007–2016 - Volume 24, Number 5—May 2018 - Emerging Infectious Diseases journal - CDC
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Published in |
Emerging Infectious Diseases, May 2018
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DOI | 10.3201/eid2405.171830 |
Pubmed ID | |
Authors |
Andrew Fox-Lewis, Junko Takata, Thyl Miliya, Yoel Lubell, Sona Soeng, Poda Sar, Kolthida Rith, Gregor McKellar, Vanaporn Wuthiekanun, Erin McGonagle, Nicole Stoesser, Catrin E. Moore, Christopher M. Parry, Claudia Turner, Nicholas P.J. Day, Ben S. Cooper, Paul Turner |
Abstract |
To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin-gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | 13% |
Chile | 1 | 13% |
United States | 1 | 13% |
Vietnam | 1 | 13% |
Thailand | 1 | 13% |
Australia | 1 | 13% |
Brazil | 1 | 13% |
Unknown | 1 | 13% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 124 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 22% |
Student > Master | 16 | 13% |
Student > Doctoral Student | 11 | 9% |
Student > Ph. D. Student | 11 | 9% |
Student > Postgraduate | 9 | 7% |
Other | 18 | 15% |
Unknown | 32 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 22% |
Immunology and Microbiology | 11 | 9% |
Agricultural and Biological Sciences | 8 | 6% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Nursing and Health Professions | 6 | 5% |
Other | 21 | 17% |
Unknown | 44 | 35% |