Title |
Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
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Published in |
Breast Cancer Research, June 2010
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DOI | 10.1186/bcr2596 |
Pubmed ID | |
Authors |
Göran Jönsson, Johan Staaf, Johan Vallon-Christersson, Markus Ringnér, Karolina Holm, Cecilia Hegardt, Haukur Gunnarsson, Rainer Fagerholm, Carina Strand, Bjarni A Agnarsson, Outi Kilpivaara, Lena Luts, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Niklas Loman, Per Malmström, Håkan Olsson, Oskar Th Johannsson, Adalgeir Arason, Heli Nevanlinna, Rosa B Barkardottir, Åke Borg |
Abstract |
Breast cancer is a profoundly heterogeneous disease with respect to biologic and clinical behavior. Gene-expression profiling has been used to dissect this complexity and to stratify tumors into intrinsic gene-expression subtypes, associated with distinct biology, patient outcome, and genomic alterations. Additionally, breast tumors occurring in individuals with germline BRCA1 or BRCA2 mutations typically fall into distinct subtypes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 2 | 1% |
Germany | 1 | <1% |
France | 1 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Norway | 1 | <1% |
Denmark | 1 | <1% |
Argentina | 1 | <1% |
Other | 2 | 1% |
Unknown | 143 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 49 | 31% |
Student > Ph. D. Student | 27 | 17% |
Student > Bachelor | 14 | 9% |
Student > Master | 11 | 7% |
Other | 8 | 5% |
Other | 23 | 15% |
Unknown | 24 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 32% |
Medicine and Dentistry | 37 | 24% |
Biochemistry, Genetics and Molecular Biology | 23 | 15% |
Computer Science | 5 | 3% |
Mathematics | 3 | 2% |
Other | 12 | 8% |
Unknown | 26 | 17% |