Chapter title |
Pathogenesis and Vaccination of Influenza A Virus in Swine.
|
---|---|
Chapter number | 391 |
Book title |
Influenza Pathogenesis and Control - Volume I
|
Published in |
Current topics in microbiology and immunology, July 2014
|
DOI | 10.1007/82_2014_391 |
Pubmed ID | |
Book ISBNs |
978-3-31-911154-4, 978-3-31-911155-1
|
Authors |
Rajao DS, Anderson TK, Gauger PC, Vincent AL, Daniela S. Rajao, Tavis K. Anderson, Phillip C. Gauger, Amy L. Vincent, Rajao, Daniela S., Anderson, Tavis K., Gauger, Phillip C., Vincent, Amy L. |
Abstract |
Swine influenza is an acute respiratory disease of pigs caused by influenza A virus (IAV) and characterized by fever followed by lethargy, anorexia, and serous nasal discharge. The disease progresses rapidly and may be complicated when associated with other respiratory pathogens. IAV is one of the most prevalent respiratory pathogens of swine, resulting in substantial economic burden to pork producers. In the past 10-15 years, a dramatic evolution of the IAV in U.S. swine has occurred, resulting in the co-circulation of many antigenically distinct IAV strains, derived from 13 phylogenetically distinct hemagglutinin clusters of H1 and H3 viruses. Vaccination is the most common strategy to prevent influenza in pigs, however, the current diverse IAV epidemiology poses a challenge for the production of efficacious and protective vaccines. A concern regarding the use of traditional inactivated vaccines is the possibility of inducing vaccine-associated enhanced respiratory disease (VAERD) when vaccine virus strains are mismatched with the infecting strain. In this review, we discuss the current epidemiology and pathogenesis of swine influenza in the United States, different vaccines platforms with potential to control influenza in pigs, and the factors associated with vaccine-associated disease enhancement. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Unknown | 59 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 18% |
Student > Master | 9 | 15% |
Student > Bachelor | 7 | 11% |
Student > Ph. D. Student | 6 | 10% |
Professor | 5 | 8% |
Other | 16 | 26% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 12 | 20% |
Immunology and Microbiology | 10 | 16% |
Agricultural and Biological Sciences | 9 | 15% |
Medicine and Dentistry | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Other | 9 | 15% |
Unknown | 7 | 11% |