Chapter title |
Strategies to Block Bacterial Pathogenesis by Interference with Motility and Chemotaxis
|
---|---|
Chapter number | 493 |
Book title |
How to Overcome the Antibiotic Crisis
|
Published in |
Current topics in microbiology and immunology, March 2016
|
DOI | 10.1007/82_2016_493 |
Pubmed ID | |
Book ISBNs |
978-3-31-949282-7, 978-3-31-949284-1
|
Authors |
Erhardt, Marc, Marc Erhardt |
Abstract |
Infections by motile, pathogenic bacteria, such as Campylobacter species, Clostridium species, Escherichia coli, Helicobacter pylori, Listeria monocytogenes, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Salmonella species, Vibrio cholerae, and Yersinia species, represent a severe economic and health problem worldwide. Of special importance in this context is the increasing emergence and spread of multidrug-resistant bacteria. Due to the shortage of effective antibiotics for the treatment of infections caused by multidrug-resistant, pathogenic bacteria, the targeting of novel, virulence-relevant factors constitutes a promising, alternative approach. Bacteria have evolved distinct motility structures for movement across surfaces and in aqueous environments. In this review, I will focus on the bacterial flagellum, the associated chemosensory system, and the type-IV pilus as motility devices, which are crucial for bacterial pathogens to reach a preferred site of infection, facilitate biofilm formation, and adhere to surfaces or host cells. Thus, those nanomachines constitute potential targets for the development of novel anti-infectives that are urgently needed at a time of spreading antibiotic resistance. Both bacterial flagella and type-IV pili (T4P) are intricate macromolecular complexes made of dozens of different proteins and their motility function relies on the correct spatial and temporal assembly of various substructures. Specific type-III and type-IV secretion systems power the export of substrate proteins of the bacterial flagellum and type-IV pilus, respectively, and are homologous to virulence-associated type-III and type-II secretion systems. Accordingly, bacterial flagella and T4P represent attractive targets for novel antivirulence drugs interfering with synthesis, assembly, and function of these motility structures. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 1% |
Unknown | 98 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 19% |
Student > Bachelor | 13 | 13% |
Researcher | 10 | 10% |
Other | 8 | 8% |
Student > Master | 7 | 7% |
Other | 18 | 18% |
Unknown | 24 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 20 | 20% |
Immunology and Microbiology | 15 | 15% |
Agricultural and Biological Sciences | 15 | 15% |
Medicine and Dentistry | 5 | 5% |
Nursing and Health Professions | 2 | 2% |
Other | 13 | 13% |
Unknown | 29 | 29% |