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Synthetic mRNA

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Attention for Chapter 15: Synthetic mRNA
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Chapter title
Synthetic mRNA
Chapter number 15
Book title
Synthetic mRNA
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3625-0_15
Pubmed ID
Book ISBNs
978-1-4939-3623-6, 978-1-4939-3625-0
Authors

Devi, Gayathri R, Nath, Sritama, Devi, Gayathri R., Gayathri R. Devi, Sritama Nath

Abstract

Dendritic cell (DC)-based vaccines are commonly used for cancer immunotherapy. To prepare vaccines, DCs are pulsed or transfected with either: (a) defined peptides of tumor-associated antigens, (b) total protein isolated from the tumor cell, (c) autologous total RNA isolated from the tumor cell, (d) synthetic tumor-antigen-encoding mRNA, or (e) genes that encode for specific tumor-associated antigens. Introduction of tumor-associated antigen(s) and subsequent generation of mature DCs that can stimulate tumor-antigen-specific cytotoxic T lymphocytes comprise the critical steps of cancer vaccine preparation. Here, we described a method of: (a) preparing and delivering synthetic FOXP3 mRNA into human DCs, (b) generating mature DCs,

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Other 2 14%
Student > Master 2 14%
Researcher 2 14%
Student > Bachelor 1 7%
Other 1 7%
Unknown 3 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 21%
Immunology and Microbiology 3 21%
Agricultural and Biological Sciences 2 14%
Medicine and Dentistry 1 7%
Engineering 1 7%
Other 0 0%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2016.
All research outputs
#15,577,316
of 23,923,788 outputs
Outputs from Methods in molecular biology
#4,965
of 13,508 outputs
Outputs of similar age
#225,230
of 399,687 outputs
Outputs of similar age from Methods in molecular biology
#479
of 1,460 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,508 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,687 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,460 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.