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Synthetic mRNA

Overview of attention for book
Cover of 'Synthetic mRNA'

Table of Contents

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    Book Overview
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    Chapter 1 Synthetic mRNA
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    Chapter 2 Synthetic Capped mRNAs for Cap-Specific Photo-Cross-Linking Experiments
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    Chapter 3 Enzymatic Modification of 5′-Capped RNA and Subsequent Labeling by Click Chemistry
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    Chapter 4 Preparation of Functional, Fluorescently Labeled mRNA Capped with Anthraniloyl-m 7 GpppG
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    Chapter 5 Intronless β -Globin Reporter: A Tool for Studying Nuclear RNA Stability Elements
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    Chapter 6 Synthetic mRNA
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    Chapter 7 Synthetic mRNA
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    Chapter 8 Synthetic mRNA
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    Chapter 9 Synthetic mRNA
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    Chapter 10 Synthetic mRNA
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    Chapter 11 Synthetic mRNA
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    Chapter 12 Synthetic mRNA
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    Chapter 13 Synthetic mRNA
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    Chapter 14 Transfection of Human Keratinocytes with Nucleoside-Modified mRNA Encoding CPD-Photolyase to Repair DNA Damage
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    Chapter 15 Synthetic mRNA
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    Chapter 16 Synthetic mRNA
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    Chapter 17 Synthetic mRNA
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    Chapter 18 Synthetic mRNA
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    Chapter 19 Synthetic mRNA
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    Chapter 20 Measuring Hematocrit in Mice Injected with In Vitro-Transcribed Erythropoietin mRNA
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    Chapter 21 Genetic Modification of Human Pancreatic Progenitor Cells Through Modified mRNA
Attention for Chapter 16: Synthetic mRNA
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Chapter title
Synthetic mRNA
Chapter number 16
Book title
Synthetic mRNA
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3625-0_16
Pubmed ID
27236804
Book ISBNs
978-1-4939-3623-6, 978-1-4939-3625-0
Authors

Borch, Troels Holz, Svane, Inge Marie, Met, Özcan, Troels Holz Borch, Inge Marie Svane, Özcan Met

Abstract

Dendritic cells are known to be the most potent antigen presenting cell in the immune system and are used as cellular adjuvants in therapeutic anticancer vaccines using various tumor-associated antigens or their derivatives. One way of loading antigen into the dendritic cells is by mRNA electroporation, ensuring presentation of antigen through major histocompatibility complex I and potentially activating T cells, enabling them to kill the tumor cells. Despite extensive research in the field, only one dendritic cell-based vaccine has been approved. There is therefore a great need to elucidate and understand the immunological impact of dendritic cell vaccination in order to improve clinical benefit. In this chapter, we describe a method for performing immune monitoring using peripheral blood mononuclear cells and autologous dendritic cells transfected with tumor-associated antigen-encoding mRNA.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 29%
Researcher 2 29%
Student > Master 1 14%
Unknown 2 29%
Readers by discipline Count As %
Immunology and Microbiology 3 43%
Agricultural and Biological Sciences 2 29%
Medicine and Dentistry 1 14%
Unknown 1 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2016.
All research outputs
#16,122,040
of 23,923,788 outputs
Outputs from Methods in molecular biology
#5,612
of 13,508 outputs
Outputs of similar age
#237,278
of 399,687 outputs
Outputs of similar age from Methods in molecular biology
#551
of 1,460 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,508 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,687 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,460 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.

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