| Chapter title |
Liposomes
|
|---|---|
| Chapter number | 15 |
| Book title |
Liposomes
|
| Published in |
Methods in molecular biology, November 2016
|
| DOI | 10.1007/978-1-4939-6591-5_15 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6589-2, 978-1-4939-6591-5
|
| Authors |
Bertrand, Nicolas, Simard, Pierre, Leroux, Jean-Christophe, Nicolas Bertrand, Pierre Simard, Jean-Christophe Leroux |
| Abstract |
pH-sensitive liposomes have been designed to deliver active compounds, specifically to acidic intracellular organelles, and to augment their cytoplasmic concentrations. These systems combine the protective effects of other liposomal formulations with specific environment-controlled drug release. They are stable at physiological pH, but abruptly discharge their contents when endocytosed into acidic compartments, allowing the drug to be released before it is exposed to the harsh environment of the lysosomes.Serum-stable formulations with minimal leakage at physiological pH and rapid drug release at pH 5.0 to 5.5 can be easily prepared by inserting a hydrophobically modified N-isopropylacrylamide/methacrylic acid copolymer (poly(NIPAM-co-MAA)) in the lipid bilayer of sterically stabilized liposomes. The present chapter describes polymer synthesis, as well as the preparation and characterization of large unilamellar pH-sensitive vesicles. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 70% |
| Professor | 1 | 10% |
| Student > Bachelor | 1 | 10% |
| Researcher | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 30% |
| Biochemistry, Genetics and Molecular Biology | 2 | 20% |
| Chemistry | 2 | 20% |
| Agricultural and Biological Sciences | 1 | 10% |
| Materials Science | 1 | 10% |
| Other | 1 | 10% |