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Liposomes

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Cover of 'Liposomes'

Table of Contents

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    Book Overview
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    Chapter 1 Liposomes
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    Chapter 2 Thin-Film Hydration Followed by Extrusion Method for Liposome Preparation
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    Chapter 3 Preparation of DRV Liposomes
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    Chapter 4 Method of Simultaneous Analysis of Liposome Components Using HPTLC/FID
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    Chapter 5 Freeze-Fracture Electron Microscopy on Domains in Lipid Mono- and Bilayer on Nano-Resolution Scale
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    Chapter 6 Liposome Formulations of Hydrophobic Drugs
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    Chapter 7 A “Dock and Lock” Approach to Preparation of Targeted Liposomes
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    Chapter 8 Coupling of Ligands to the Liposome Surface by Click Chemistry
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    Chapter 9 Elastic Liposomes for Topical and Transdermal Drug Delivery
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    Chapter 10 Determination of the Subcellular Distribution of Liposomes Using Confocal Microscopy
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    Chapter 11 Liposomes
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    Chapter 12 Liposome Biodistribution via Europium Complexes
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    Chapter 13 Techniques for Loading Technetium-99m and Rhenium-186/188 Radionuclides into Preformed Liposomes for Diagnostic Imaging and Radionuclide Therapy
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    Chapter 14 Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes
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    Chapter 15 Liposomes
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    Chapter 16 Long-Circulating, pH-Sensitive Liposomes
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    Chapter 17 Anionic pH-Sensitive Lipoplexes
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    Chapter 18 Fluorometric Analysis of Individual Cationic Lipid–DNA Complexes
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    Chapter 19 Preparation and Physical Characterization of DNA-Binding Cationic Liposomes
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    Chapter 20 Fluorescence Resonance Energy Transfer (FRET)-Based Analysis of Lipoplexes
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    Chapter 21 Targeted Magnetic Liposomes Loaded with Doxorubicin
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    Chapter 22 Stable Discoidal Bicelles: A Platform of Lipid Nanocarriers for Cellular Delivery
Attention for Chapter 4: Method of Simultaneous Analysis of Liposome Components Using HPTLC/FID
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Chapter title
Method of Simultaneous Analysis of Liposome Components Using HPTLC/FID
Chapter number 4
Book title
Liposomes
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6591-5_4
Pubmed ID
Book ISBNs
978-1-4939-6589-2, 978-1-4939-6591-5
Authors

Sophia Hatziantoniou, Costas Demetzos, Hatziantoniou, Sophia, Demetzos, Costas

Abstract

Liposomes are composed of different kind of lipids or lipophilic substances and are used as carriers of bioactive molecules. The characterization of the prepared liposomes consists of the calculation of the drug to lipid molar ratio by measuring the lipids and the encapsulated molecule.The present work describes an analytical methodology on simultaneous determination of all the lipid ingredients of the liposome formulation, using Thin Layer Chromatography coupled with a Flame Ionization Detector (TLC/FID), using the least possible sample quantity. The method consists of a chromatographic separation of the liposomal ingredients on silica gel scintillated on quartz rods and subsequent detection of the ingredients by scanning the rods by hydrogen flame. The produced ions are detected by a Flame Ionization Detector and the signal is converted to a chromatogram.This method may be applied on every step of the liposome preparation for examining the quality of the raw materials, tracking possible errors of the preparation procedure and finally analyzing the content of the final liposomal composition.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 25%
Researcher 1 25%
Unknown 2 50%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 50%
Unknown 2 50%