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DNA Replication

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Cover of 'DNA Replication'

Table of Contents

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    Book Overview
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    Chapter 1 Historical Perspective of Eukaryotic DNA Replication
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    Chapter 2 Regulation of Replication Origins
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    Chapter 3 Molecular Mechanism for Chromatin Regulation During MCM Loading in Mammalian Cells
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    Chapter 4 Initiation of DNA Replication at the Chromosomal Origin of E. coli , oriC
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    Chapter 5 Initiation of DNA Replication in the Archaea
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    Chapter 6 Mechanism of Lagging-Strand DNA Replication in Eukaryotes
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    Chapter 7 Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication
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    Chapter 8 Termination of Eukaryotic Replication Forks
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    Chapter 9 Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex
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    Chapter 10 Architecture of the Saccharomyces cerevisiae Replisome
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    Chapter 11 Replication Domains: Genome Compartmentalization into Functional Replication Units
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    Chapter 12 Rif1-Dependent Regulation of Genome Replication in Mammals
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    Chapter 13 G-Quadruplexes and DNA Replication Origins
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    Chapter 14 Interaction of Rif1 Protein with G-Quadruplex in Control of Chromosome Transactions
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    Chapter 15 Chromatin Replication and Histone Dynamics
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    Chapter 16 The Temporal Regulation of S Phase Proteins During G1
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    Chapter 17 Roles of SUMO in Replication Initiation, Progression, and Termination
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    Chapter 18 The Multiple Roles of Ubiquitylation in Regulating Challenged DNA Replication
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    Chapter 19 Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System
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    Chapter 20 Coordinating Replication with Transcription
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    Chapter 21 Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites
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    Chapter 22 Cyclin E Deregulation and Genomic Instability
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    Chapter 23 Replication Through Repetitive DNA Elements and Their Role in Human Diseases
Attention for Chapter 22: Cyclin E Deregulation and Genomic Instability
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Chapter title
Cyclin E Deregulation and Genomic Instability
Chapter number 22
Book title
DNA Replication
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-981-10-6955-0_22
Pubmed ID
Book ISBNs
978-9-81-106954-3, 978-9-81-106955-0
Authors

Leonardo K. Teixeira, Steven I. Reed, Teixeira, Leonardo K., Reed, Steven I.

Abstract

Precise replication of genetic material and its equal distribution to daughter cells are essential to maintain genome stability. In eukaryotes, chromosome replication and segregation are temporally uncoupled, occurring in distinct intervals of the cell cycle, S and M phases, respectively. Cyclin E accumulates at the G1/S transition, where it promotes S phase entry and progression by binding to and activating CDK2. Several lines of evidence from different models indicate that cyclin E/CDK2 deregulation causes replication stress in S phase and chromosome segregation errors in M phase, leading to genomic instability and cancer. In this chapter, we will discuss the main findings that link cyclin E/CDK2 deregulation to genomic instability and the molecular mechanisms by which cyclin E/CDK2 induces replication stress and chromosome aberrations during carcinogenesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 15%
Researcher 7 15%
Student > Bachelor 3 6%
Student > Doctoral Student 3 6%
Other 3 6%
Other 7 15%
Unknown 17 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 45%
Agricultural and Biological Sciences 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Economics, Econometrics and Finance 1 2%
Psychology 1 2%
Other 1 2%
Unknown 18 38%