Chapter title |
Echocardiographic Assessment in Patients with Granulomatosis with Polyangiitis
|
---|---|
Chapter number | 43 |
Book title |
Clinical Management of Pulmonary Disorders and Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/5584_2017_43 |
Pubmed ID | |
Book ISBNs |
978-3-31-969544-0, 978-3-31-969545-7
|
Authors |
Katarzyna Życińska, Anna Borowiec, Tadeusz M. Zielonka, Tomasz Rusinowicz, Małgorzata Hadzik-Błaszczyk, Magda Cieplak, Kazimierz A. Wardyn, Życińska, Katarzyna, Borowiec, Anna, Zielonka, Tadeusz M., Rusinowicz, Tomasz, Hadzik-Błaszczyk, Małgorzata, Cieplak, Magda, Wardyn, Kazimierz A. |
Abstract |
Granulomatosis with polyangiitis (GPA) is one of the most common forms of systemic vasculitis, which usually involves the upper and lower respiratory tract, but it may affect also multiple organs. The aim of the study was an echocardiographic evaluation of cardiac involvement in GPA patients during remission. Eighty eight patients with GPA were evaluated in the study. The control group consisted of 40 age and sex-matched patients without a previous history of cardiovascular disease. We found that there were no differences between GPA and control groups regarding left atrial enlargement and interventricular septal hypertrophy. In one GPA patient, all heart chambers were enlarged. Left ventricle systolic function was decreased (LVEF ≤ 50%) in eight patients with GPA, and left ventricle wall motion abnormalities were observed in 12 patients. Left ventricle relaxation dysfunction, mitral valve and tricuspid valve regurgitation were observed with the same frequency in both GPA and control groups. Aortic regurgitation was the single abnormality that occurred significantly more often in the GPA group than in controls (28% vs. 7.5%; p = 0.03). Pericardial effusion was observed in three GPA patients and in none from the control group. We conclude that the most common echocardiographic manifestation in GPA patients in remission was aortic valve regurgitation. However, cardiac involvement in such patients is rather rare and in the majority of cases clinically insignificant. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 1 | 13% |
Librarian | 1 | 13% |
Student > Bachelor | 1 | 13% |
Researcher | 1 | 13% |
Student > Postgraduate | 1 | 13% |
Other | 0 | 0% |
Unknown | 3 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 63% |
Unknown | 3 | 38% |