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Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls

Overview of attention for article published in Clinical Epigenetics, March 2018
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Title
Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls
Published in
Clinical Epigenetics, March 2018
DOI 10.1186/s13148-018-0472-5
Pubmed ID
Authors

Fu-Ying Tian, Xi-Meng Wang, Chuanbo Xie, Bo Zhao, Zhongzheng Niu, Lijun Fan, Marie-France Hivert, Wei-Qing Chen

Abstract

Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely known as a mechanism of fetal growth. However, it is unclear whether and how DNA methylation of FGFR2 gene in the placenta is associated with full-term low birth weight. This case-control study aims to explore the links between FGFR2 methylation in placenta and full-term low birth weight and to further examine the mediation effect of placental surface area on this association. We conducted analyses for each of the five valid CpG sites at FGFR2 in 165 mother-baby pairs (86 FT-LBW vs. 79 FT-NBW) and found that per one standard deviation increase in the DNA methylation of CpG 11 at FGFR2 was associated with 1.64-fold higher risk of full-term low birth weight (OR = 1.64, 95% CI = [1.07, 2.52]) and 0.18 standard deviation decrease in placental surface area (β = - 0.18; standard error = 0.08, p = 0.02). The mediation effect of placental surface area on the association between DNA methylation and full-term low birth weight was significant in girls (OR = 1.38, 95% CI = [1.05, 1.80]) but not in boys. The estimated mediation proportion was 48.38%. Our findings suggested that placental surface area mediated the association between DNA methylation of FGFR2 in placenta and full-term low birth weight in a sex-specific manner. Our study supported the importance of placental epigenetic changes in placental development and fetal growth.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 18%
Student > Doctoral Student 3 14%
Researcher 2 9%
Student > Bachelor 2 9%
Professor 1 5%
Other 1 5%
Unknown 9 41%
Readers by discipline Count As %
Medicine and Dentistry 4 18%
Biochemistry, Genetics and Molecular Biology 2 9%
Agricultural and Biological Sciences 2 9%
Nursing and Health Professions 1 5%
Psychology 1 5%
Other 2 9%
Unknown 10 45%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2019.
All research outputs
#10,951,764
of 14,414,290 outputs
Outputs from Clinical Epigenetics
#579
of 757 outputs
Outputs of similar age
#192,706
of 277,013 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 1 outputs
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