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Molecular regulation of pancreatic stellate cell function

Overview of attention for article published in Molecular Cancer, October 2004
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2 Wikipedia pages

Citations

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135 Dimensions

Readers on

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106 Mendeley
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1 Connotea
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Title
Molecular regulation of pancreatic stellate cell function
Published in
Molecular Cancer, October 2004
DOI 10.1186/1476-4598-3-26
Pubmed ID
Authors

Robert Jaster

Abstract

Until now, no specific therapies are available to inhibit pancreatic fibrosis, a constant pathological feature of chronic pancreatitis and pancreatic cancer. One major reason is the incomplete knowledge of the molecular principles underlying fibrogenesis in the pancreas. In the past few years, evidence has been accumulated that activated pancreatic stellate cells (PSCs) are the predominant source of extracellular matrix (ECM) proteins in the diseased organ. PSCs are vitamin A-storing, fibroblast-like cells with close morphological and biochemical similarities to hepatic stellate cells (also known as Ito-cells). In response to profibrogenic mediators such as various cytokines, PSCs undergo an activation process that involves proliferation, exhibition of a myofibroblastic phenotype and enhanced production of ECM proteins. The intracellular mediators of activation signals, and their antagonists, are only partially known so far. Recent data suggest an important role of enzymes of the mitogen-activated protein kinase family in PSC activation. On the other hand, ligands of the nuclear receptor PPARgamma (peroxisome proliferator-activated receptor gamma) stimulate maintenance of a quiescent PSC phenotype. In the future, targeting regulators of the PSC activation process might become a promising approach for the treatment of pancreatic fibrosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 3 3%
Switzerland 1 <1%
France 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 99 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 31%
Researcher 22 21%
Student > Master 13 12%
Student > Bachelor 10 9%
Student > Doctoral Student 8 8%
Other 11 10%
Unknown 9 8%
Readers by discipline Count As %
Medicine and Dentistry 31 29%
Agricultural and Biological Sciences 30 28%
Biochemistry, Genetics and Molecular Biology 23 22%
Engineering 4 4%
Immunology and Microbiology 3 3%
Other 6 6%
Unknown 9 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2017.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Molecular Cancer
#692
of 1,918 outputs
Outputs of similar age
#24,743
of 76,378 outputs
Outputs of similar age from Molecular Cancer
#4
of 4 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,378 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.