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Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease

Overview of attention for article published in Stem Cell Research & Therapy, April 2018
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Mentioned by

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6 tweeters

Citations

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3 Dimensions

Readers on

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21 Mendeley
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Title
Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease
Published in
Stem Cell Research & Therapy, April 2018
DOI 10.1186/s13287-018-0843-z
Pubmed ID
Authors

Amaya Rando, Diego Pastor, Mari Carmen Viso-León, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta, Salvador Martínez

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen as a potential therapeutic approach. SOD1 mutant mice were used to study the potential neurotrophic effect of bone marrow cells grafted into quadriceps femoris muscle. Bone marrow intramuscular transplants resulted in increased longevity with improved motor function and decreased motoneuron degeneration in the spinal cord. Moreover, the increment of the glial-derived neurotrophic factor and neurotrophin 4 observed in the grafted muscles suggests that this partial neuroprotective effect is mediated by neurotrophic factor release at the neuromuscular junction level. Finally, certain neurodegeneration and muscle disease-specific markers, which are altered in the SOD1G93Amutant mouse and may serve as molecular biomarkers for the early detection of ALS in patients, have been studied with encouraging results. This work demonstrates that stem cell transplantation in the muscle prolonged the lifespan, increased motoneuron survival and slowed disease progression, which was also assessed by genetic expression analysis.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Researcher 3 14%
Student > Bachelor 3 14%
Professor 2 10%
Student > Doctoral Student 1 5%
Other 4 19%
Unknown 3 14%
Readers by discipline Count As %
Neuroscience 6 29%
Biochemistry, Genetics and Molecular Biology 4 19%
Agricultural and Biological Sciences 3 14%
Arts and Humanities 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 3 14%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2019.
All research outputs
#7,935,421
of 14,123,515 outputs
Outputs from Stem Cell Research & Therapy
#558
of 1,291 outputs
Outputs of similar age
#136,115
of 276,472 outputs
Outputs of similar age from Stem Cell Research & Therapy
#1
of 1 outputs
Altmetric has tracked 14,123,515 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,291 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,472 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them