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Behavioral Neurobiology of Anxiety and Its Treatment

Overview of attention for book
Cover of 'Behavioral Neurobiology of Anxiety and Its Treatment'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Pharmacotherapy of Social Anxiety Disorder
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    Chapter 2 Pharmacological treatment of generalized anxiety disorder.
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    Chapter 3 Antidepressant Treatment in Anxiety Disorders
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    Chapter 4 Anxiety disorders diagnosis: some history and controversies.
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    Chapter 5 Functional neuroanatomy of anxiety: a neural circuit perspective.
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    Chapter 6 Genetics
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    Chapter 7 Neuroanatomy of Anxiety
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    Chapter 8 The Pharmacology of Anxiety
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    Chapter 9 Epidemiology of Anxiety Disorders
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    Chapter 10 Pharmacological Enhancement of Behavioral Therapy: Focus on Posttraumatic Stress Disorder
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    Chapter 11 Behavioral Correlates of Anxiety
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    Chapter 12 Pharmacological Treatment of Obsessive-Compulsive Disorder
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    Chapter 13 Stress and the Neuroendocrinology of Anxiety Disorders
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    Chapter 14 Developing Small Molecule Nonpeptidergic Drugs for the Treatment of Anxiety Disorders: Is the Challenge Still Ahead?
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    Chapter 15 Pharmacotherapy of Post-Traumatic Stress Disorder
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    Chapter 16 Cannabinoids and anxiety.
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    Chapter 17 Animal Models of Anxiety and Anxiolytic Drug Action
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    Chapter 30 GABA A Receptor α2/α3 Subtype-Selective Modulators as Potential Nonsedating Anxiolytics
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    Chapter 31 Genetic Approaches to Modeling Anxiety in Animals
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    Chapter 32 Comorbidity in Anxiety Disorders
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    Chapter 33 Challenging Anxiety: A Focus on the Specificity of Respiratory Symptoms
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    Chapter 35 Pharmacologic Treatment of Panic Disorder
  24. Altmetric Badge
    Chapter 36 Metabotropic Glutamate Receptors: Their Therapeutic Potential in Anxiety
Attention for Chapter 16: Cannabinoids and anxiety.
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 363)
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
16 news outlets
twitter
2 tweeters
facebook
19 Facebook pages

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
75 Mendeley
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Chapter title
Cannabinoids and anxiety.
Chapter number 16
Book title
Behavioral Neurobiology of Anxiety and Its Treatment
Published in
Current topics in behavioral neurosciences, February 2011
DOI 10.1007/7854_2009_16
Pubmed ID
Book ISBNs
978-3-64-202911-0, 978-3-64-202912-7
Authors

Moreira FA, Wotjak CT, Fabrício A. Moreira, Carsten T. Wotjak, Moreira, Fabrício A., Wotjak, Carsten T.

Abstract

The term cannabinoids encompasses compounds produced by the plant Cannabis sativa, such as delta9-tetrahydrocannabinol, and synthetic counterparts. Their actions occur mainly through activation of cannabinoid type 1 (CB1) receptors. Arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol (2-AG) serve as major endogenous ligands (endocannabinoids) of CB1 receptors. Hence, the cannabinoid receptors, the endocannabinoids, and their metabolizing enzymes comprise the endocannabinoid system. Cannabinoids induce diverse responses on anxiety- and fear-related behaviors. Generally, low doses tend to induce anxiolytic-like effects, whereas high doses often cause the opposite. Inhibition of endocannabinoid degradation seems to circumvent these biphasic effects by enhancing CB1 receptor signaling in a temporarily and spatially restricted manner, thus reducing anxiety-like behaviors. Pharmacological blockade or genetic deletion of CB1 receptors, in turn, primarily exerts anxiogenic-like effects and impairments in extinction of aversive memories. Interestingly, pharmacological blockade of Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel, which can be activated by anandamide as well, has diametrically opposite consequences. This book chapter summarizes and conceptualizes our current knowledge about the role of (endo)cannabinoids in fear and anxiety and outlines implications for an exploitation of the endocannabinoid system as a target for new anxiolytic drugs.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 19%
Student > Master 13 17%
Researcher 13 17%
Professor > Associate Professor 7 9%
Student > Bachelor 6 8%
Other 15 20%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 21%
Neuroscience 12 16%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Psychology 7 9%
Biochemistry, Genetics and Molecular Biology 6 8%
Other 10 13%
Unknown 15 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 119. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2020.
All research outputs
#173,355
of 15,808,355 outputs
Outputs from Current topics in behavioral neurosciences
#1
of 363 outputs
Outputs of similar age
#1,580
of 157,754 outputs
Outputs of similar age from Current topics in behavioral neurosciences
#1
of 3 outputs
Altmetric has tracked 15,808,355 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 363 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them